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Metabolomics

Published: Apr, 2015 | Pages: 498 | Publisher: RESEARCH IMPACT TECHNOLOGIES
Industry: Biotechnology | Report Format: Electronic (PDF)

This report gives an insight into Metabolomics Technologies - Combined/Integrated Systems, Hardware Systems for metabolic analytics, and Software Systems. Estimations and predictions for the total global Metabolomics Technologies' market are given by geographic regions encompassing United States, Canada, Europe, Asia-Pacific, and Japan. Business profiles of more than 25 major companies are discussed in the report. The report covers more than 200 companies that are engaged in Metabolomics research and supply of products and/or services. Major Contract Research Organizations and Universities serving Metabolomics market are also covered in the Corporate Directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, and mergers and acquisitions is also covered in the report. Compilation of Worldwide Patents and Research related to Metabolomics is also provided. A total of 49 graphically represented exhibits complement the text.
 Table of Content
I. SCOPE AND METHODOLOGY	1
2. REPORT SYNOPSIS	3
2.1 Introduction	3
Segmentation of Metabolomics Technologies	4
2.3 Global Market Analysis	5
Exhibit 1. Metabolomics - Global Market Estimations & Predictions (2005 - 2020) in US$ Million	5
Exhibit 2. List of Major Global Metabolomics Companies	6
3. MARKET DYNAMICS	7
3.1 Metabolomics – Market Overview	7
3.2 Global Metabolomics Market	7
Exhibit 3. Metabolomics - Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Japan, Asia-Pacific, and Rest of World in US$ Million	8
Exhibit 4. Metabolomics – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Japan, Asia-Pacific, and Rest of World	9
3.3 North American Metabolomics Market	10
Exhibit 5. Metabolomics – North American Market Estimations & Predictions (2005 - 2020) for United States, and Canada in US$ Million	10
Exhibit 6. Metabolomics – North American Market Shares (2010, 2015 & 2020) by Country for United States, and Canada	11
3.3 (I) United States Metabolomics Market	11
3.3 (II) Canadian Metabolomics Market	11
Exhibit 7. List of Major North American Metabolomics Companies	11
3.4 European Metabolomics Market	13
Exhibit 8. Metabolomics – European Market Estimations & Predictions (2005-2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain, Switzerland, Sweden,  Russia and Rest of Europe in US$ Million	13
Exhibit 9. Metabolomics – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain, Switzerland, Sweden, Russia and Rest of Europe	14
3.4 (I) German Metabolomics Market	14
3.4 (II) UK Metabolomics Market	14
3.4 (III) Italian Metabolomics Market	14
3.4 (IV) Belgian Metabolomics Market	14
3.4 (V) French Metabolomics Market	14
3.4 (VI) Spanish Metabolomics Market	15
3.4 (VII) Swiss Metabolomics Market	15
3.4 (VIII) Swedish Metabolomics Market	15
3.4 (IX) Russian Metabolomics Market	15
Exhibit 10. List of Major European Metabolomics Companies	15
3.5 Asia-Pacific Metabolomics Market	16
Exhibit 11. Metabolomics – Asia-Pacific Market Estimations & Predictions (2005-2020) by Country for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific in US$ Million	16
Exhibit 12. Metabolomics – Asia-Pacific Market Shares (2010, 2015 & 2020) for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific	17
3.5 (I) Japanese Metabolomics Market	17
3.5 (II) Chinese Metabolomics Market	17
3.5 (III) Indian Metabolomics Market	17
3.5 (IV) Australian Metabolomics Market	18
3.5 (IV) South Korean Metabolomics Market	18
Exhibit 13. List of Major Asia-Pacific Metabolomics Companies	18
3.6 Rest of World Metabolomics Market	19
Exhibit 14. Metabolomics – Rest of World Market Estimations & Predictions (2005 – 2015) for Israel, South Africa, Brazil and Other Countries in US$ Million	19
Exhibit 15. Metabolomics – Rest of World Market Shares (2010, 2015 & 2020) for Israel, South Africa, Brazil and Other Countries	20
3.6 (I) Israeli Metabolomics Market	20
3.6 (II) South African Metabolomics Market	20
3.6 (III) Brazilian Metabolomics Market	20
Exhibit 16. List of Major Rest of World Metabolomics Companies	20
3.7 Company Profiles – Major Players in Metabolomics Market	21
AB SCIEX (USA)	21
Accelrys, Inc. (USA)	22
Acureomics AB (Sweden)	23
Agilent Technologies, Inc. (USA)	23
Amatsi Group (France)	25
Berg LLC (USA)	28
BIOCRATES Life Sciences AG (Austria)	28
Bio-Rad Laboratories, Inc. (USA)	30
Bruker Corporation (USA)	32
Chenomx, Inc. (Canada)	34
HepatoChem, Inc. (USA)	35
Human Metabolome Technologies, Inc. (Japan)	36
IROA Technologies (USA)	37
LECO Corporation (USA)	38
Max Planck Society (The) (Germany)	40
Metabolomic Discoveries GmbH (Germany)	42
Metabolomics Australia (Australia)	44
Metabolomx (USA)	44
Metabolon, Inc. (USA)	45
Metabometrix Ltd. (UK)	46
metanomics GmbH (Germany)	47
Phenomenome Discoveries, Inc. (Canada)	48
Shimadzu Corporation (Japan)	49
SiDMAP (USA)	51
Stemina Biomarker Discovery, Inc. (USA)	52
Thermo Fisher Scientific, Inc. (USA)	53
Waters Corporation (USA)	56
Xceleron, Inc. (USA)	57
3.8 Major Activities in Metabolomics Market	58
Berg Collaborates with Medical University of South Carolina for Lupus Biomarker Discovery	58
G3 Partners with Caprion to Conduct GLOBAL Study to detect Cardiovascular Disease Biomarkers and Drug Targets	58
SRI International in Association with NHLBI Establishes Metabolite Standards Synthesis Center	58
University of Alberta Metabolomics Research Team Collaborates with BGI Shenzhen on New Cancer Screening Technology	59
Waters Corporation Acquires Nonlinear Dynamics	59
IMDEA Food Enters into Strategic Collaboration with Metabolon to Advance nutrition-based personalized Medicine	59
AB Sciex in Association with Genedata and LECO Announces Partnership for New Cross-Platform Metabolomics Data Analysis Solution	60
Bruker and SCiLS GmbH Enters into Exclusive Collaboration for SCiLS Lab Software for MALDI Imaging	60
Agilent Technologies and Applied Proteomics Form an Alliance to Maximize Capabilities of Highly Multiplexed Protein Assays	60
LECO Corp., and AB SCIEX Enters into Collaboration to offer Combined GC/MS and LC/MS Solutions for Metabolomics Research	61
Thermo Fisher Scientific Enters into Technology Partnership with the University of Birmingham	61
Chenomx and Spain’s Center for Omic Sciences Collaborates on Metabolomics Consulting Projects	61
Agilent Technologies’ New Pathway Architect Software to include SRI International’s BioCyc Pathway Database Collection	62
Agilent Technologies and Spain’s Center for Omic Sciences Collaborates on Integrated Systems Biology Research, Establish Center of Excellence	62
Bruker Enters into Collaboration with Nextval to combine ultrafleXtreme™ with MassInsight™ High-Throughput Platform	62
Agilent Technologies’ and PREMIER Biosoft’s Join Hands to Advance Lipidomics Research	63
Genedata Alliances with LECO for Mass Spectrometry Data Analysis for High Resolution TOFMS Systems	63
Agilent Technologies Collaborates with Molecular Discovery to Address Complex Problems in Drug Research and Development	63
AB Sciex Enters into Agreement with Sigma-Aldrich for Distribution of iChemistry™ Solutions	63
Metabolon Acquires Lipomics Technologies	64
Waters and Nonlinear Dynamics Co-Develops Next Generation Research Solutions	64
Agilent Technologies Collaborates with Samsung Medical Center on Clinical Research Projects	64
Agilent Technologies Establishes Neuro-Metabolomics Research and Training Center in City of Daegu	65
Takeda Enters into Research Collaboration with Metabolon to Discover Novel Targets and Biomarkers	65
AB SCIEX to Commercially Expand in Brazil	65
AB Sciex Initiates Academic Partnership Program	66
Vitalea Science and Accium BioSciences Initiates Two-Way Cooperative Agreement to Cross-Validate Accelerator Mass Spectrometer (AMS) Resources	66
BIOCRATES Expands Its European Distribution Network to Spain and Turkey	67
AB SCIEX and Indigo in Collaboration to Accelerate Adoption of Next-generation Mass Spectrometry for Clinical Research, Forensic Toxicology and Clinical Trials	67
Tecan and Waters in OEM Agreement	67
Sygnature Discovery and Cyprotex Extend Successful Strategic Alliance for a Further Two Years	67
Vermillion Acquires Ovarian Cancer Diagnostics Business of Correlogic Systems'	68
PerkinElmer Acquires Caliper Life Sciences	68
AB SCIEX Acquires Mass Spectrometry Division of Labindia to Expand its Presence in India	68
Absorption Systems Forms Pharmacokinetics Collaboration with Leading Scientist	69
Particle Sciences Joins Hands with Absorption Systems	69
Takeda Obtains License to Use Additional Features of Genedata Expressionist, for Improving its Mass Spectrometry based Research	69
AMRI Enters into Agreement with Proteros Biostructures GmbH	70
Advion BioServices Inaugurates Midwest Drug Discovery and Metabolism Center of Excellence	70
Novus Biologicals and GeneGo in Collaboration	71
Ricerca Biosciences and Fulcrum Pharma, the Aptiv Solutions Company, in Strategic Collaboration Agreement	71
Agilent Acquires Biocius and Lab901	71
Agilent Technologies Acquires Assets of A2 Technologies	72
Sigma-Aldrich Takes Over Cerilliant Corporation	73
SGS Acquires M-Scan	73
Metabolomic Discoveries Enters into Licensing Agreement with Max Planck	73
Thomson Reuters Acquires GeneGo	73
MDS Inc., Changes Corporate Identity	74
USFDA Selects AB SCIEX’s Mass Spectrometry Systems	74
USPTO Grants Patent to Metabolon Inc	74
AB SCIEX Collaborates with the University of Melbourne for Development of Innovative Method for Drug Metabolism Studies of Biopharmaceuticals	74
Genego Enters into Collaboration with Omicsoft	75
Metabolon Receives Patent for Determining Metabolic Age of an Individual	75
Cyprotex Acquires Apredica	75
Agilent Technologies Enters into Research Partnership with Johns Hopkins University	76
Victoria’s New Agricultural Biosciences Research Center Established	76
AB SCIEX Partners with the ETH Zurich Institute of Molecular Systems Biology	76
Accelrys and Symyx Technologies Complete Merger to Create Leading Scientific Informatics Software Company	76
Shimadzu and ACD/Labs Form Partnership	77
Entelos Agrees for License Terms Expansion with Pfizer	77
Agilent Technologies Acquires Varian Inc.	77
Agilent Technologies and Stemina Biomarker Discovery Announce Joint Efforts	77
Thermo Fisher Scientific Takes Over Proxeon	78
Symyx Enters into Partnership with Simulations Plus	78
Biocrates Signs Co-Marketing Agreement with Chenomx Inc.	78
AB SCIEX Takes Over Eksigent Liquid Chromatography Business	78
Danaher Buys AB SCIEX and Molecular Devices	79
Molecular Biometrics Raises Series B Funding	79
SBIR Grant for GeneGo	80
Partnership Between Process NMR Associates and Topnir	80
Metabolomics Used to Discover Biomarkers for Periodontal Disease	80
Beckman Coulter Acquires Cogenics	81
SiDMAP Forays into Japanese Market	81
Genedata and Syngenta Extend Biomarker Discovery Collaboration	81
Quotient Bioscience Acquires Pharmaceutical Profiles and Elaborates Metabolic Sciences Services Offerings	81
Applied Biosystems and Invitrogen Merge	82
Nanosyn Inaugurates Service Facility	82
Syngenta Gets Access to Metabolons Biochemical Profiling Technology	82
Thermo Fisher Scientific Collaborates with Genedata for Metabolomics Research	83
UCB Collaborates with BioSeek for Evaluation of Compounds with BioMAP Systems	83
Bruker BioSciences to Acquire Privately Held Bruker BioSpin’s Companies	83
Agreement Gives U.S Food and Drug Administration an Access to Genedata Expressionist Platform	84
GeneGo Grants License for Usage of MetaCore to Oregon Health and Science University (OHSU)’s Facility	84
Metabolon Collaborates with US Army Medical Research Institute of Infectious Diseases	85
Metabolon Acquires Cogenics Icoria’s Patented Metabolomics and Toxicity Technologies	85
Bionas Enters into a Service Contract with Solvay Pharmaceuticals	85
GeneGo Licenses MetaCore to Biogen Idec	86
Chenomx Partners with GeneGo to Provide Metabolomics Data Integration	86
HMT Explains the Cause of Heterogeneity in Bacillus Subtilis Populations	87
Chenomx Inc. Awarded two Patents for NMR-based Mixture Analysis Computations	87
Nanosys and Bruker Daltonics Collaborate for Research, Development and Distribution of NALDI(TM)-TOF	88
MDS Acquires Entire Stake in MDC	88
Agilent Technologies Collaborates with Lipomics for Developing Research and Diagnostic Biomarker Assays	89
BG Medicine and Applied Biosystems Collaborate for Improving Biomarker Discovery and Development	89
AstraZeneca Employs ToxWiz to Determine the Effects of Liver Treatment Drugs	90
Nycomed Acquires ALTANA Pharma AG	90
Bayer AG Takes Over Schering AG	91
GeneData Enters into Collaboration with Serono for Intensifying Analysis on Screening	91
GenoLogics’ Proteus™ to be Utilized by University of Leuven	91
GenoLogics’ Geneus Solution to be Utilized for Genomics Research	91
Clinical Data Signs Pact with QTC	92
Ariadne Grants Pathway Studio License to NCI	92
GeneData Enters into Collaboration with Altana and Introduces Hit Profiler	93
Agilent Signs Agreement with Mass Consortium	93
Bruker BioSciences Acquires Stake in Bruker Optics	93
GeneData Signs Partnership Agreement with INCA	93
Shimadzu Signs Partnership Agreement with Phenomenome	94
PathwayStudio® 4.0 of Ariadne Links up with Affymetrix GeneChip-compatible Applications Program	94
Cerep Signs Licensing Agreement with AstraZeneca	94
Chenomx Joins Hands with Umetrics to Offer Metabolomics Solution	94
Biocrates Signs Alliance Agreement with Altana	95
Bio-Rad Enters into Partnership with Infometrix	95
NCTR Establishes Metabolomics Research Center	95
Syngenta Acquires Licenses from InforSense	96
Clinical Data Initiates Metabolomics Research of Lung Cancer Samples	96
CST Extends Agreement with AstraZeneca	96
3.9 Major Product Innovations/Launches in Metabolomics Market	97
Waters Introduces Advanced software Packages for Proteomics And Metabolomics/Lipidomics Analyses	97
Metabolon Launches 4th Generation DiscoveryHD4™ Metabolomics Platform	97
Cerilliant Launches New Certified Snap-N-Spike® Solutions of Phenethylamines	97
HepatoChem Introduces BioMimetic Oxidation (BMO) Kit	98
Cerilliant Launches New Snap-N-Spike® Internal Standards of Nicotine Metabolites	98
Cyprotex Launches its Latest 'Mechanisms of Drug-Induced Toxicity' Guide	98
Bruker Launches New Mass Spectrometry Systems and Solutions for Life-Science Research, Clinical Research, Pharmaceutical and Applied Markets	99
Agilent Technologies Launches Advanced Mass Spectrometry Software	99
Agilent Technologies Enhances LC and LC/MS Systems	100
Agilent Technologies Introduces RapidFire 365 High-throughput Mass Spectrometry System	100
AB Sciex Introduces Three New Solutions for Biological Research	101
AB Sciex Launches Windows 7-Compatible Software for Triple Quadrupoles and QTRAP® Systems	101
Metabolon Launches New Truevision™ Metabolomics Range	101
Agilent Technologies Launches Improved NMR Data-Acquisition Software	102
Bruker Launches Instant Expertise in High Resolution LCMSMS with the New COMPACT Mass Spectrometer	103
BIOCRATES Launches Thermo Edition of AbsoluteIDQ®p150	103
AB Sciex Launches 3200MD Series	103
Cerilliant Launches 13C-Labeled Internal Standards for Thyroid Hormone Testing by LC-MS/MS	104
Selventa Designs Powerful new Class of Multi-omic based Diagnostic Test for Autoimmune Disease and Cancer	104
Human Metabolome Technologies Establishes Office in Cambridge, Massachusetts	105
Cerilliant Launches New Certified Spiking Solutions® of Nicotine Metabolites and Nitrosamines	105
Bruker Launches PesticideScreener™ Solution	105
Bruker Launches eXtreme Resolution (XR™) in Mass Spectrometry	105
BIOCRATES Life Sciences Launches Full Set of Reagents for MS-based Steroid Analysis	106
Insilico and Metabolic Discoveries Launches Media Optimization Kit and Cell Line Engineering Kit	106
BASF’s Subsidiary Metanomics Health Introduces MetaMap®Tox	107
Cyprotex Launches New ADME/Tox Services	107
Bruker Launches New ultrafleXtreme MALDI-TOF/TOF Mass Spectrometer	108
BIOCRATES Life Sciences AG Launches Waters Xevo® TQ MS Editions for AbsoluteIDQ® p180 and p150 Research Kit Products	108
AB Sciex Launches Amplifex™ Reagents	108
AB SCIEX Launches TripleTOF 4600	109
Agilent Technologies Clubs Integrated Biology Capabilities to Bioinformatics Suite	109
Expression CMS, a Compact Mass Spectrometer, Commercially Launched by Advion	109
Cerilliant Launches Snap-N-Spike® Certified Reference Solutions of Catecholamines	110
Bruker Launches SCION Series GC-MS Detectors	110
AB SCIEX Expands Eksigent Microflow UHPLC Capabilities	110
Metabolomx Develops a New Breath Test for Lung Cancer Detection	110
Bruker Extends its Gas Chromatography Product Portfolio with the Launch of SHS-40 Automated Headspace Sampler	111
Cyprotex Adds gADME™, a pioneering Human Pharmacokinetics based Research Service	111
Metabolon Launches Its Asian Facility in Shanghai	112
RIKEN Discovers New Method for Understanding the Dynamics of Specific Metabolites in Plant Cells	112
Bruker Launches amaZon speed™ Next-Generation Ion Trap Mass Spectrometers	113
Puracyp and Promega Combine Cell Lines and Assay Systems to Offer Complete Solution for Drug Development	113
Roche’s Accu-Chek Aviva Plus Test Strips for Diabetics Gets the US FDA Nod	114
Covance Inc. Extends its Drug Metabolism Platform to Eight Human Transporters to Modulate Drug Disposition	114
Metabolon Secures US$ 13 Million in Series D Financing	115
Absorption Systems Files Patent Application	115
US Patent to Entelos for Predictive Toxicology for Biological Systems	115
BIOCRATES Unveils MetaDisIDQ Kit	116
Genego Integrates MetaCore with Agilent’s Genespring Bioinformatics Solution	116
Waters Corp., Launches New Program to Support Scientific Innovations	116
Thermo Fisher Launches Mass Frontier 7.0	116
Agilent Technologies Introduces GeneSpring GX 11.5	116
ACD/Labs and FDA in Development Collaboration for Predictive QSAR Models	117
ETH Zurich Develops Proteomics MRM Atlas	117
Genego Integrates MetaCore & MetaDrug with Genomequest for Sequence Data Management (SDM)	117
BIOCRATES Life Sciences Launches AbsoluteIDQ p180 Kit	118
Phoenix Introduces LC Column Heaters and Controllers	118
Shimadzu Launches New Accurate Glycan Analyzer	118
SiDMAP Announces Results from a Study on a novel Roche drug for Type 2 diabetes	119
GeneGo Launches ToxHunter Tools for Systems Toxicology Research	119
Shimadzu Corp., Launches Comprehensive Two Dimensional Chromatography with GCxGC Analysis	119
Dionex Enhances HPLC Products Range	120
Genedata Launches Expressionist 6	120
Thermo Fisher Scientific Unveils MetQuest Automated Metabolic Screening Software	120
AB Sciex Introduces TripleTOF™ 5600 System	121
Absorption Systems Integrates Thermo Scientific’s LTQ Orbitrap XL	121
LabLogic Introduces a New Version of LIMS	121
Entelos Granted US Patent for Innovative Diagnostic Capability in Obesity, Diabetes	122
RIKEN Creates World’s First Database for Secondary Metabolites from Plant Parts	122
Shimadzu Introduces Tandem Quadrupole LC-MS System – LCM 8030	122
Absorption Systems Launches New Drug Metabolism Assays	123
Lablogic Enhances LIMS Debra	124
Accelrys Launches NMR Analysis Collection	124
Agilent Technologies Introduces High Throughput Injectors for UHPLC	124
Metabolon Receives Patent for Metabolomics Software	125
Advion BioServices Enhances the LC/MS Biomarker Service unit	125
Covance Expands Service Capacity and Expertise for Metabolite Identification	126
Thermo Fisher Scientific Introduces the LTQ Velos and LTQ Velos Orbitrap	126
BioFocus Strengthens ADME/PK Laboratory Bioanalytical Capabilities	126
UPLC/MS Systems Acquired by National Cancer Institute for Metabolomics Research	127
Bio-Rad Incorporates Automatic Filtering of NMR Spectra (AFNS) of University of Wisconsin-Madison in to KnowItAll® Metabolomics Software	127
Metabolon Launches Third Generation Metabolomics Platform	128
Chenomx, Inc. Launches the Upgraded Version of Metabolomics Software Solution	128
Metabolon to Provide mVision™ Service for Biomarker Discovery	129
Chenomx Inc. Introduces Metabolic Profiling Services	130
Applied Biosystems Launches StepOne™ Real-Time PCR System	130
Applied Biosystems Introduces TaqMan®	130
Discovery of APG16L1, as a New Gene Related to Crohn’s Disease	131
InnoMed Introduces a New Website for Data Transmission	131
GenoLogics Discovers Sophisticated Data Management Solutions for Various Applications	131
Phoenix Launches SureSpray Technology	132
Bio-Rad Releases Version 7.5 of its KnowItAll Informatics System	132
GenoLogics Introduces Geneus™	133
Ariadne Introduces Additional Pathway Database for PathwayStudio® and PathwayExpert™ Software	133
Thermo Electron (now Thermo Fisher Scientific) Launches Galileo LIMS v 3.2	134
Agilent Launches Liquid Chromatography (LC) Column	134
Ariadne Introduces New Software for Pathway Analysis	134
GeneData Launches Expressionist® Pro 3.0	134
Applied Biosystems and MDS Unveil MIDAS™ TRAQ Systems	135
Applied Biosystems and MDS Introduce Tempo™, a Liquid Chromatography (LC) System	135
GenoLogics Develops OmixLIMS	135
GeneGo Incorporates Accord technology in MetaDrug™	136
Applied Biosystems and MDS Sciex Unveil MarkerView™ Software	136
Phenomenome Develops Solution for Colorectal Cancer Screening	136
Bio-Rad Laboratories Introduces ADMET Databases	137
Thermo Electron (now Thermo Fisher Scientific) Introduces LeadStream ADME/Tox Solution™	137
3.10 Analysis by Technologies	138
Exhibit 17. Metabolomic Technologies – Global Market Estimations & Predictions (2005-2020) for Combined Systems, Hardware Systems and Software Systems in US$ Million	138
Exhibit 18. Metabolomic Technologies – Global Market Shares (2010, 2015 & 2020) for Combined Systems, Hardware Systems and Software Systems	139
3.10.1 Combined Systems – The Fastest Growing Technology	140
3.10.1.1 Global Combined Metabolomics Systems Market	140
Exhibit 19. Combined Metabolomics Systems - Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Japan, Asia-Pacific and Rest of World in US$ Million	141
Exhibit 20. Combined Metabolomics Systems - Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Japan, Asia-Pacific, and Rest of World	142
3.10.1.2 North American Combined Metabolomics Systems Market	143
Exhibit 21. Combined Metabolomics Systems – North American Market Estimations & Predictions (2005-2020) by Country for United States and Canada in US$ Million	143
Exhibit 22. Combined Metabolomics Systems – North American Shares (2010, 2015 & 2020) by Country for United States and Canada	144
3.10.1.2 (I) United States Combined Metabolomics Systems Market	144
3.10.1.2 (II) Canadian Combined Metabolomics Systems Market	144
3.10.1.3 European Combined Metabolomics Systems Market	145
Exhibit 23. Combined Metabolomics Systems – European Market Estimations & Predictions (2005-2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain, Switzerland, Sweden, Russia and Rest of Europe in US$ Million	145
Exhibit 24. Combined Systems* of Metabolomics – European Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain, Switzerland, Sweden, Russia and Rest of Europe	146
3.10.1.3 (I) German Combined Metabolomics Systems Market	146
3.10.1.3 (II) UK Combined Metabolomics Systems Market	146
3.10.1.3 (III) Italian Combined Metabolomics Systems Market	146
3.10.1.3 (IV) Belgian Combined Metabolomics Systems Market	146
3.10.1.3 (V) French Combined Metabolomics Systems Market	147
3.10.1.3 (VI) Spanish Combined Metabolomics Systems Market	147
3.10.1.3 (VII) Swiss Combined Metabolomics Systems Market	147
3.10.1.3 (VIII) Swedish Combined Metabolomics Systems Market	147
3.10.1.3 (IX) Russian Combined Metabolomics Systems Market	147
3.10.1.4 Asia-Pacific Combined Metabolomics Systems Market	148
Exhibit 25. Combined Metabolomics Systems – Asia-Pacific Market Estimations & Predictions (2005-2020) in US$ Million by Country for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific	148
Exhibit 26. Combined Metabolomics Systems – Asia-Pacific Shares (2010, 2015 & 2020) by Country for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific	149
3.10.1.4 (I) Japanese Combined Metabolomics Systems Market	149
3.10.1.4 (II) Chinese Combined Metabolomics Systems Market	149
3.10.1.4 (III) Indian Combined Metabolomics Systems Market	149
3.10.1.4 (IV) Australian Combined Metabolomics Systems Market	149
3.10.1.4 (V) South Korean Combined Metabolomics Systems Market	149
3.10.1.5 Rest of World Combined Metabolomics Systems Market	150
Exhibit 27. Combined Metabolomics Systems– Rest of World Market Estimations & Predictions (2005-2020) for Israel, South Africa, Brazil and Other Countries in US$ Million	150
Exhibit 28. Combined Metabolomics Systems– Rest of World Market Shares (2010, 2015 & 2020) for Israel, South Africa, Brazil and Other Countries	151
3.10.1.5 (I) Israeli Combined Metabolomics Systems Market	151
3.10.1.5 (II) South African Combined Metabolomics Systems Market	151
3.10.1.5 (III) Brazilian Combined Metabolomics Systems Market	151
3.10.2 Hardware Systems - The Fading-out Technology	152
3.10.2.1 Global Metabolomics Hardware Systems Market	152
Exhibit 29. Metabolomics Hardware Systems - Global Market Estimations & Predictions (2005 – 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	152
Exhibit 30. Metabolomics Hardware Systems - Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	153
3.10.2.2 North American Metabolomics Hardware Systems Market	154
Exhibit 31. Metabolomics Hardware Systems – North American Market (2005-2020) by Country for United States and Canada in US$ Million	154
Exhibit 32. Metabolomics Hardware Systems – North American Shares (2010, 2015 & 2020) by Country for United States and Canada	155
3.10.2.2 (I) United States Metabolomics Hardware Systems Market	155
3.10.2.2 (II) Canadian Metabolomics Hardware Systems Market	155
3.10.2.3 European Metabolomics Hardware Systems Market	156
Exhibit 33. Metabolomics Hardware Systems – European Market Estimations & Predictions (2005-2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain,  Switzerland, Sweden, Russia and Rest of Europe in US$ Million	156
Exhibit 34. Metabolomics Hardware Systems– European Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain, Switzerland, Sweden, Russia and Rest of Europe	157
3.10.2.3 (I) German Metabolomics Hardware Systems Market	157
3.10.2.3 (II) UK Metabolomics Hardware Systems Market	157
3.10.2.3 (III) Italian Metabolomics Hardware Systems Market	157
3.10.2.3 (IV) Belgian Metabolomics Hardware Systems Market	157
3.10.2.3 (V) French Metabolomics Hardware Systems Market	158
3.10.2.3 (VI) Spanish Metabolomics Hardware Systems Market	158
3.10.2.3 (VII) Swiss Metabolomics Hardware Systems Market	158
3.10.2.3 (VIII) Swedish Metabolomics Hardware Systems Market	158
3.10.2.3 (IX) Russian Metabolomics Hardware Systems Market	158
3.10.2.4 Asia-Pacific Metabolomics Hardware Systems Market	159
Exhibit 35. Metabolomics Hardware Systems – Asia-Pacific Market Estimations & Predictions (2005-2020) by Country for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific in US$ Million	159
Exhibit 36. Metabolomics Hardware Systems – Asia-Pacific Shares (2010, 2015 & 2020) by Country for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific	160
3.10.2.4 (I) Japanese Metabolomics Hardware Systems Market	160
3.10.2.4 (II) Chinese Metabolomics Hardware Systems Market	160
3.10.2.4 (III) Indian Metabolomics Hardware Systems Market	160
3.10.2.4 (IV) Australian Metabolomics Hardware Systems Market	160
3.10.2.4 (V) South Korean Metabolomics Hardware Systems Market	160
3.10.2.6 Rest of World Metabolomics Hardware Systems Market	161
Exhibit 37. Metabolomics Hardware Systems– Rest of World Market Estimations & Predictions (2005-2020) for Israel, South Africa, Brazil and Other Countries in US$ Million	161
Exhibit 38. Hardware Systems* of Metabolomics – Rest of World Market Shares (2010, 2015 & 2020) for Israel, South Africa, Brazil and Other Countries	162
3.10.2.5 (I) Israeli Metabolomics Hardware Systems Market	162
3.10.2.5 (II) South African Metabolomics Hardware Systems Market	162
3.10.2.5 (III) Brazilian Metabolomics Hardware Systems Market	162
3.10.3 Software Systems – Ever Growing in Emerging Markets	163
3.10.3.1 Global Metabolomics Software Systems Market	163
Exhibit 39. Metabolomics Software Systems - Global Market Estimations & Predictions (2005 - 2015) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	163
Exhibit 40. Metabolomics Software Systems - Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World.	164
3.10.3.2 North American Metabolomics Software Systems Market	165
Exhibit 41. Metabolomics Software Systems – North American Market (2005-2020) by Country for United States and Canada in US$ Million	165
Exhibit 42. Metabolomics Software Systems – North American Shares (2010, 2015 & 2020) by Country for United States and Canada	166
3.10.3 (I) United States Metabolomics Software Systems Market	166
3.10.3 (II) Canadian Metabolomics Software Systems Market	166
3.10.3.3 European Metabolomics Software Systems Market	167
Exhibit 43. Metabolomics Software Systems – European Market Estimations & Predictions (2005-2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain, Switzerland, Sweden, Russia and Rest of Europe in US$ Million	167
Exhibit 44. Metabolomics Software Systems– European Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, Italy, Belgium, France, Spain, Switzerland, Sweden, Russia and Rest of Europe	168
3.10.3.3 (I) German Metabolomics Software Systems Market	168
3.10.3.3 (II) UK Metabolomics Software Systems Market	168
3.10.3.3 (III) Italian Metabolomics Software Systems Market	168
3.10.3.3 (IV) Belgian Metabolomics Software Systems Market	168
3.10.3.3 (V) French Metabolomics Software Systems Market	169
3.10.3.3 (VI) Spanish Metabolomics Software Systems Market	169
3.10.3.3 (VII) Swiss Metabolomics Software Systems Market	169
3.10.3.3 (VIII) Swedish Metabolomics Software Systems Market	169
3.10.3.3 (IX) Russian Metabolomics Software Systems Market	169
3.10.3.4 Asia-Pacific Metabolomics Software Systems Market	170
Exhibit 45. Metabolomics Software Systems – Asia-Pacific Market Estimations & Predictions (2005-2020) by Country for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific in US$ Million	170
Exhibit 46. Metabolomics Software Systems – Asia-Pacific Shares (2009 & 2015) by Country for China, India, Australia, Japan, South Korea and Rest of Asia-Pacific	171
3.10.3.4 (I) Japanese Metabolomics Software Systems Market	171
3.10.3.4 (II) Chinese Metabolomics Software Systems Market	171
3.10.3.4 (III) Indian Metabolomics Software Systems Market	171
3.10.3.4 (IV) Australian Metabolomics Software Systems Market	171
3.10.3.4 (V) South Korean Metabolomics Software Systems Market	171
3.10.3.6 Rest of World Metabolomics Software Systems Market	172
Exhibit 47. Metabolomics Software Systems – Rest of World Market Estimations & Predictions (2005-2020) for Israel, South Africa, Brazil and Other Countries in US$ Million	172
Exhibit 48. Metabolomics Software Systems – Rest of World Market Shares (2010, 2015 & 2020) for Israel, South Africa, Brazil and Other Countries	173
3.10.3.5 (I) Israeli Metabolomics Software Systems Market	173
3.10.3.5 (II) South African Metabolomics Software Systems Market	173
3.10.3.5 (III) Brazilian Metabolomics Software Systems Market	173
3.11 Metabolomics – Market Outlook	174
4. PRODUCT/TECHNOLOGY RESEARCH	178
4.1 Introduction	178
Backdrop	178
Metabolomics – The Definition	179
Metabolism: Metabolites and Metabolome	179
Metabolites	179
Secondary Metabolites	179
Metabolome	180
Metabolic Profiling	180
Metabolomics and Metabonomics	181
History of Metabolomics	181
Metabolomic Profiling	182
Separation Methods	182
Detection Methods	182
Metabolomic Profiling – The Applications	182
Toxicity Assessment/Toxicology	182
Functional Genomics	183
Human Nutrition Metabolome	183
Metabolomics and Human Health	183
Metabolomic Techniques for Genetic Mapping	184
Human Metabolic Diagnosis	184
Metabolomics in Human Nutrition – Prospects and Experiments	185
The Human Nutrition Metabolome Generation	186
Pattern-Recognition Methods and Human Nutrition	187
Nutrition Evaluation with Pharmacology and Toxicology	187
Metabolomic Profiling – Tools	187
HiRes (High Resolution Spectroscopy)	187
Computer Simulation of Metabolism	188
Computer Simulation and the Design of Drugs	188
Cheminformatics	189
The Human Metabolome Project	189
Human Metabolome Database	189
Importance of Metabolomic Studies	190
Systems Biology or Integrative Biology	191
System Biology and its Inside View	192
Biomolecular Networks	193
Metabolic Activity Preservation in Lyophilized human Erythrocytes	193
Metabolic flux ratio study on Escherichia coli mutants using GC-MS method	193
Metabolite Profiling – The Technologies	194
The LC-MS Technique	194
Liquid Chromatographic Radioactivity Detection Techniques	195
Structural Genomics in Combination with Metabolic Profiling	195
Techniques for Redox Metabolic Profiling	195
How Metabolites Affect Food	195
Metabolomics - Related with other Omics?	196
Proteomics, Genomics and Metabolomics	196
Functional Genomics	197
The Shortcomings/Delays in Functional Genomics Strategies	197
Proteomics	198
Lipidomics	199
Definition	199
Concept of Lipidomics	200
Traditional Analysis of Lipids	200
Lipidomics Aids in Treatment for CNS Related Diseases	200
Glycomics	201
Study of Glycobiology - Analytical High-Throughput Technologies	201
Transcriptomics	201
Arabidopsis Thaliana	202
Signal Transduction Process	202
Dietary Leucine Excess	203
Analysis of Metabolic Pathways	203
Types of Metabolic Pathways Databases	203
MMCD	203
BRENDA	204
EMP	204
Enzyme Nomenclature Database	204
IntEnz	204
Kinase Pathway Database	204
PhosphaBase	205
PRECISE	205
TECRDB	205
BOCD	205
EcoCyc	205
KEGG Metabolic Pathways	206
Boehringer Mannheim - Biochemical Pathways	206
Environmental Metabolomics	206
Components for the Study of Metabolomics	206
Challenges to Environmental Metabolomics	207
Advantages of Metabolomics	207
Other Side of the Coin	207
Metabolomics to Probe GM Foods	208
4.2 Metabolomics Technologies	209
Sophisticated Analytical Tools Required in Metabolomics	209
Scope for Growth in NMR-based Analysis	210
The Bottom-up Approach	210
Blood as a Central Focus Theme	211
An Individualized Approach to Metabolomics	212
Categorization of Metabolomics Technologies	212
Exhibit 49. Estimated Proportion of Metabolomics’ Technologies	213
Mass Spectrometry	213
Applications of Mass Spectrometers	214
Protein Detection and Analysis	214
Full MS and MS2 spectra of a peptide	214
Protein Quantitation	214
Protein Structure Probing	214
Space Exploration	215
Respiratory Gas Monitoring	215
Isotope Ratio Evaluation	215
Exposure and Burial Dating	215
Trace Gas Analysis	216
Pharmacokinetics	216
Metabolites Identification and Biomarkers Development	216
Exhibit 50. Use of Metabolomic to Improve Detection of Cancers	217
Metabolomics in Cancer Research	217
Nuclear Magnetic Resonance	218
Fourier Spectroscopy	218
Multi-Dimensional – A Type of FT-NMR	218
NMR Based Metabolomics	218
Applications of NMR	219
Liquid Chromatography/ Gas Chromatography	220
High Performance Liquid Chromatography	220
Lab-on-a-Chip	220
Capillary Electrophoresis	221
Electrochemical Array	221
Application of Electrochemical Array Detection in Metabolomics	221
Fourier-Transform Infrared Spectroscopy	222
Qualitative Analysis with FT – IR7	222
Challenges for Metabolomics	222
4.3 Metabolomics – A Pharma and Healthcare Perspective	223
Metabolomics - Significance on Individual Health	223
Need for Awareness of Balanced Diet	223
Creation of Basic Structure	224
Creation Stage	224
Development of Technologies	224
Database Collection on Personalized Metabolites Health	225
Innovation Stage	225
Metabolism’s Role in Physical Condition	225
Pathways Ideal for Classifying Targets and Techniques	225
Execution Stage	226
Execution of Personalized Evaluation Technologies	226
Clinical Chemistry and Metabolomics	226
Metabolomics in Biomarker Identification	227
Metabolite Biomarkers	228
Study of Biomarker Metabolites in Oryza Sativa (Rice)	228
Limitations of Metabolite Biomarkers	229
Personalized Medicine with Metabolomics	229
Pharmaco-Metabonomics	229
Application of Metabolomics in Transplantation	230
Exhibit 51. Reported Frequencies of Organ Transplantations (2008): Percentage Breakdown of Frequencies for Kidney, Liver, Heart, Pancreas and Lung Transplantations	230
Role of Metabolomics in Transplantation of Various Organs	230
Exhibit 52. Increased Concentration of Metabolite Related to Organ Transplantation	231
Exhibit 53. Decreased Concentration of Metabolite Related to Organ Transplantation	232
Kidney Transplantation	232
Liver Transplantation	233
Heart Transplantation	233
Metabolomics – In the Process of Drug Discovery	233
Metabolomics to Save Time and Cost in Initial Stages	234
Distinguishing Varieties of Animal Phenotypes	235
Use in Personalized Nutrition Research and Clinical Field	235
Challenges Associated with Metabolomics for Diabetes Research	236
Biomarker Detection	236
Metabolic Profiling Approach for Biomarker Discovery	237
ESI-LC/MS use in Identifying Biomarkers in Plant Extracts	237
Metabolic Profiles and Biomarkers Determines Toxic Drug Effects	237
4.4 Metabolomics – Research Briefs	238
Study Demonstrates Cancer Cutting Risks of Green Tea	238
Metabolimics and Gestational Type 2 Diabetes	238
Analysis of Importance of Metabolites' Role in Understanding Disease	239
Eating Fish Increase Good Cholesterol Levels	240
Researchers Discover Metabolic Signals to Diabetic Kidney Failure	241
Numerous Advantages Coming from One Type of Omega-3 fatty acid: DHA	241
Health Enhancement Products’ Proprietary ProAlgaZyme Reduces Cholesterol	242
Metabolomics Used in Secondary Metabolite Research	243
Oxantel: Potential Curative for Peridontitis	246
Mitochondrial Dysfunction in Diabetic Kidney Disease	247
Latest about Type-2 Diabetes	248
Chemical Makeup of Urine Decoded	248
Caffeine to the Rescue	249
Biochemical Mapping Enables the Response to Antidepressants	250
Biolog's Phenotype MicroArray Technology Unlocks Critical Clue in Understanding Autism	251
Targeted in Vitro Technique may Enhance Insulin Resistance among Offspring	252
Pyruvate Dehydrogenase: New Regulator of Cellular Senescence	252
Would Blood Test Identify Alzheimer’s in an Early Stage	253
New Serum Biomarker Bilirubin Helps to Predict Lung Cancer Risk in Smokers	254
Tumor Specific Enzymes: Potential Targets for Anti-Carinogens	255
Novel Metabolite-based Diagnostic Test Capable of Identifying Pancreatic Cancer	255
Metabolomics and Pediatric Research	256
Metabolomic Study Gives Insight into the Development of Renal Disease Associated with Type 2 Diabetes	256
Metabolomics Application in Understanding Health of Ray and Shark	257
New Metabolic Signatures Potential for Therapeutic Application in glioma	258
Regular Bread Intake to Avert Cardiovascular Disease Risk	258
Fourteen New Biomarkers Identified for Type 2 Diabetes	259
Database on Metabolites Leading to Novel Discoveries	260
Metabolomics in Diabetes Studies	261
Recent Advancements in FTMS Expands its Applications	262
Olavius Algarvensis Survives on Hydrogen Sulphide & Carbon Monoxide Using Bacterial Symbionts	262
Beneficial Effects of Nuts in Controlling Metabolic Disorders	263
Advion Developing H4 Method for Clopidogrel and the Inactive Metabolites	264
Modern Technologies in Detection and Quantification of Protein Biomarkers - Mass Spectrometry and Chip LC Technology	264
Gender-Specific Drugs Developed Through Metabolomics	265
Metabolon Conducts Research into Dietary Leucine	265
Advancement in QTRAP Technology	266
SWATH™ Acquisition Technology and MRMAtlas	266
Metabolomics Investigation Gives Insight into Ovary Metabolome and Cancer-Associated Metabolic Changes -- Investigators Report from University of Louisville and Metabolon	267
Metabolomics Study Shows 3-Indoxyl Sulfate as a Sensitive and Early Biomarker of Nephrotoxicity – Investigators Report from Merck and Metabolon	268
NMS Labs and Cerilliant Corporation Declare Identification of Major Metabolite of the Synthetic Cannabinoid JWH-073	268
Metabolomics based Diagnostic Test for Schizophrenia	269
Novel Methods Used to Identify How Cigarette Smoke Affects Smokers	270
Metabolomics Investigation Gives Insight into Glioma-Associated Metabolic Changes	270
Metabolomics gives Insight into Pathogenesis of Dilated Cardiomyopathy	271
Metabolic Pathway Engineering Based on Metabolomics Provides Acetic and Formic Acid Tolerance to a Recombinant Xylose-fermenting Strain of Saccharomyces Cerevisiae	272
Protein Complex Open up the Mechanism of Innate Immunity	273
Interactive Metabolomics to Analyze Changes in Metabolome-Macromolecule Dynamics	273
Novel Genomics to Detect Auxin Inhibitor	274
Advanced NMR for Metabolite Detection	275
Diagnosis of Pneumonia with Urinary Metabolomics	275
Role of differential Glycoconjugation in the Emission of Phenylpropanoid Volatiles from Tomato Fruit	278
Dried Blood Spot Analysis with LC/MS/MS	278
Novel Normalization Method Increases the Accuracy of Mass Spectroscopy based Metabolomics	279
Evaluation and Characterization of Bacterial Metabolic Dynamics Using Real-Time Metabolotyping	280
Metabolomics Analysis Reveals the Association between Gut Microflora and Blood Metabolites	281
Characterization of the ABA- Regulated Global Responses to Dehydration in Arabidopsis Metabolomics	281
NMR Analysis of Vinegar for Adulteration Detection and Authentication	282
NMR-based Metabolic Fingerprinting and Profiling for Mini-Symposium	282
Metabolomic Profiles Indentifies Potential Role for Sarcosine in Prostate Cancer Progression	282
Metabolomics Research Studies in Breast Cancer and Prospective Applications	283
1H-NMR-based Pattern Recognition and Biomarker Validation	284
Identification of Microbial Metabolites in Mammalian Blood Using Metabolomics	284
Metabolomic Study Concerning Cisplatin-Induced Nephrotoxicity	285
V. CORPORATE DIRECTORY	286
VI. PATENTS INFORMATION	318

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