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Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Pipeline Review, H1 2016

Published: May 18, 2016 | Pages: 53 | Publisher: Global Markets Direct | Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Pipeline Review, H1 2016

Summary

Global Markets Direct's, 'Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Pipeline Review, H1 2016', provides in depth analysis on Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) targeted pipeline therapeutics. 

The report provides comprehensive information on the Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) targeted therapeutics development and features dormant and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166)
- The report reviews Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources 
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages 
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities 
- The report reviews key players involved in Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) targeted therapeutics and enlists all their major and minor projects 
- The report assesses Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type 
- The report summarizes all the dormant and discontinued pipeline projects 
- The report reviews latest news and deals related to Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) targeted therapeutics

Reasons To Buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage 
- Identify and understand the targeted therapy areas and indications for Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies 
- Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) development landscape 
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and Scope
 Table of Contents
Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) Overview 7 Therapeutics Development 8 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Products under Development by Stage of Development 8 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Products under Development by Therapy Area 9 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Products under Development by Indication 10 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Pipeline Products Glance 12 Late Stage Products 12 Early Stage Products 13 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Products under Development by Companies 14 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Products under Development by Universities/Institutes 16 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Therapeutics Assessment 18 Assessment by Monotherapy/Combination Products 18 Assessment by Mechanism of Action 19 Assessment by Route of Administration 20 Assessment by Molecule Type 22 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Companies Involved in Therapeutics Development 24 Momenta Pharmaceuticals, Inc. 24 Progen Pharmaceuticals Limited 25 Sigma-Tau S.p.A. 26 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Drug Profiles 27 Antibodies to Inhibit Heparanase for Oncology - Drug Profile 27 Product Description 27 Mechanism Of Action 27 R&D Progress 27 Drug to Inhibit Heparanase for Lung Cancer and Pancreatic Cancer - Drug Profile 28 Product Description 28 Mechanism Of Action 28 R&D Progress 28 necuparanib - Drug Profile 29 Product Description 29 Mechanism Of Action 29 R&D Progress 29 PG-545 - Drug Profile 32 Product Description 32 Mechanism Of Action 32 R&D Progress 32 Polysaccharides to Inhibit Heparanase for Oncology - Drug Profile 35 Product Description 35 Mechanism Of Action 35 R&D Progress 35 roneparstat - Drug Profile 36 Product Description 36 Mechanism Of Action 36 R&D Progress 36 Small Molecules to Inhibit Heparanase for Metastatic Cancer and Diabetic Nephropathy - Drug Profile 37 Product Description 37 Mechanism Of Action 37 R&D Progress 37 Small Molecules to Target Heparanase for Oncology, Immunology and Diabetes - Drug Profile 38 Product Description 38 Mechanism Of Action 38 R&D Progress 38 Synthetic Peptide to Inhibit HPSE and VEGF for Oncology - Drug Profile 39 Product Description 39 Mechanism Of Action 39 R&D Progress 39 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Dormant Projects 40 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Discontinued Products 41 Heparanase (Endo-Glucoronidase or Heparanase-1 or EC 3.2.1.166) - Featured News & Press Releases 42 Dec 21, 2015: Momenta Resumes Patient Enrollment in the Necuparanib (MOM-M402-103) Phase 2 Study 42 Nov 13, 2015: Momenta Announces Temporary Pause of Patient Enrollment in the Necuparanib (MOM-M402-103) Phase 2 Study 42 Jun 01, 2015: Momenta Pharmaceuticals to Present New Data From Phase 1 Trial of Necuparanib in Patients With Pancreatic Cancer 42 May 18, 2015: Momenta Pharmaceuticals Announces Data Presentation on Necuparanib (M402) at the 2015 ASCO Annual Meeting 43 Dec 01, 2014: Momenta Pharmaceuticals' Necuparanib Receives Fast Track Designation From the FDA for the Treatment of Patients With Metastatic Pancreatic Cancer 44 Oct 09, 2014: Momenta Pharmaceuticals Announces Top-Line Part A Results From Phase 1/2 Trial of Necuparanib in Patients With Pancreatic Cancer 44 Oct 09, 2014: Momenta Pharmaceuticals Announces Top-Line Part A Results From Phase 1/2 Trial of Necuparanib in Patients With Pancreatic Cancer 45 Jul 21, 2014: European Patent Office Intention to Grant 'Sulfated Oligosaccharide Derivatives' Patent 46 Jun 05, 2014: Momenta Pharmaceuticals Receives Orphan Drug Designation for Necuparanib (Formerly M402) in Pancreatic Cancer 46 Oct 29, 2013: PG545 Phase 1 Cancer Trial Update 47 Jul 09, 2013: PG545 Pre-Clinical Data in Experimental Pancreatic Cancer Models Published in Molecular Cancer Therapeutics 48 May 13, 2013: Sigma-Tau announces Phase I study with new anti-cancer heparanase inhibitor SST0001 48 Jul 02, 2012: Momenta Pharma Doses First Patient With M402 In Phase I/II Clinical Trial In Metastatic Pancreatic Cancer 49 Jun 04, 2012: Momenta Pharma Presents Positive Preclinical Results Of M402 In Combination With Gemcitabine At ASCO 2012 Annual Meeting 50 May 30, 2012: Progen Pharma Obtains Australian Patent For Heparan Sulfate Mimetic Compounds 51 Appendix 52 Methodology 52 Coverage 52 Secondary Research 52 Primary Research 52 Expert Panel Validation 52 Contact Us 52 Disclaimer 53
List of Tables
Number of Products under Development for, H1 2016 8 Number of Products under Development by Therapy Area, H1 2016 9 Number of Products under Development by Indication, H1 2016 10 Comparative Analysis by Late Stage Development, H1 2016 12 Comparative Analysis by Early Stage Products, H1 2016 13 Number of Products under Development by Companies, H1 2016 14 Products under Development by Companies, H1 2016 15 Number of Products under Investigation by Universities/Institutes, H1 2016 16 Products under Investigation by Universities/Institutes, H1 2016 17 Assessment by Monotherapy/Combination Products, H1 2016 18 Number of Products by Stage and Mechanism of Action, H1 2016 19 Number of Products by Stage and Route of Administration, H1 2016 21 Number of Products by Stage and Molecule Type, H1 2016 23 Pipeline by Momenta Pharmaceuticals, Inc., H1 2016 24 Pipeline by Progen Pharmaceuticals Limited, H1 2016 25 Pipeline by Sigma-Tau S.p.A., H1 2016 26 Dormant Projects, H1 2016 40 Discontinued Products, H1 2016 41


List of Figures
Number of Products under Development for, H1 2016 8 Number of Products under Development by Therapy Area, H1 2016 9 Number of Products under Development by Top 10 Indication, H1 2016 10 Comparative Analysis by Early Stage Products, H1 2016 13 Assessment by Monotherapy/Combination Products, H1 2016 18 Number of Products by Stage and Mechanism of Actions, H1 2016 19 Number of Products by Routes of Administration, H1 2016 20 Number of Products by Stage and Routes of Administration, H1 2016 20 Number of Products by Molecule Types, H1 2016 22 Number of Products by Stage and Molecule Type, H1 2016 22

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