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Published: Oct, 2019 | Pages:
165 | Publisher: 9Dimen Research
Industry: Food | Report Format: Electronic (PDF)
Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent. DTT's formula is C4H10O2S2 and the molecular structure of its reduced form is shown at the right; its oxidized form is a disulfide-bonded 6-membered ring. Its name derives from the four-carbon sugar, threose. DTT has an epimeric ('sister') compound, dithioerythritol (DTE).
DTT is an unusually strong reducing agent, owing to its high conformational propensity to form a six-membered ring with an internal disulfide bond. It has a redox potential of -0.33 V at pH 7. The reduction of a typical disulfide bond proceeds by two sequential thiol-disulfide exchange reactions and is illustrated below. The intermediate mixed-disulfide state is unstable (i.e., poorly populated) because the second thiol of DTT has a high propensity to close the ring, forming oxidized DTT and leaving behind a reduced disulfide bond. The reducing power of DTT is limited to pH values above ~7, since only the negatively charged thiolate form -S- is reactive (the protonated thiol form -SH is not); the pKa of thiol groups is typically ~8.3.
A common use of DTT is as a reducing or "deprotecting" agent for thiolated DNA. The terminal sulfur atoms of thiolated DNA have a tendency to form dimers in solution, especially in the presence of oxygen. Dimerization greatly lowers the efficiency of subsequent coupling reactions such as DNA immobilization on gold in biosensors. Typically DTT is mixed with a DNA solution and allowed to react, and then is removed by filtration (for the solid catalyst) or by chromatography (for the liquid form). The DTT removal procedure is often called "desalting."
DTT is frequently used to reduce the disulfide bonds of proteins and, more generally, to prevent intramolecular and intermolecular disulfide bonds from forming between cysteine residues of proteins. DTT can also be used as an oxidizing agent. Its principal advantage is that effectively no mixed-disulfide species are populated, in contrast to other agents such as glutathione.
The global Dithiothreitol Market is expect to grow at a CAGR approximately 3.5% from 2015 to 2019. Currently Asia is the largest market of Dithiothreitol, and the next five years will always remain. The European and American countries is still the DTT main import region.
In the context of China-US trade war and global economic volatility and uncertainty, it will have a big influence on this market. Dithiothreitol Report by Material, Application, and Geography - Global Forecast to 2023 is a professional and comprehensive research report on the world's major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China).
The report firstly introduced the Dithiothreitol basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the world's main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.
Table of Contents Part I Dithiothreitol Industry Overview Chapter One Dithiothreitol Industry Overview 1.1 Dithiothreitol Definition 1.2 Dithiothreitol Classification Analysis 1.2.1 Dithiothreitol Main Classification Analysis 1.2.2 Dithiothreitol Main Classification Share Analysis 1.3 Dithiothreitol Application Analysis 1.3.1 Dithiothreitol Main Application Analysis 1.3.2 Dithiothreitol Main Application Share Analysis 1.4 Dithiothreitol Industry Chain Structure Analysis 1.5 Dithiothreitol Industry Development Overview 1.5.1 Dithiothreitol Product History Development Overview 1.5.1 Dithiothreitol Product Market Development Overview 1.6 Dithiothreitol Global Market Comparison Analysis 1.6.1 Dithiothreitol Global Import Market Analysis 1.6.2 Dithiothreitol Global Export Market Analysis 1.6.3 Dithiothreitol Global Main Region Market Analysis 1.6.4 Dithiothreitol Global Market Comparison Analysis 1.6.5 Dithiothreitol Global Market Development Trend Analysis Chapter Two Dithiothreitol Up and Down Stream Industry Analysis 2.1 Upstream Raw Materials Analysis 2.1.1 Proportion of Manufacturing Cost 2.1.2 Manufacturing Cost Structure of Dithiothreitol Analysis 2.2 Down Stream Market Analysis 2.2.1 Down Stream Market Analysis 2.2.2 Down Stream Demand Analysis 2.2.3 Down Stream Market Trend Analysis Part II Asia Dithiothreitol Industry (The Report Company Including the Below Listed But Not All) Chapter Three Asia Dithiothreitol Market Analysis 3.1 Asia Dithiothreitol Product Development History 3.2 Asia Dithiothreitol Competitive Landscape Analysis 3.3 Asia Dithiothreitol Market Development Trend Chapter Four 2014-2019 Asia Dithiothreitol Productions Supply Sales Demand Market Status and Forecast 4.1 2014-2019 Dithiothreitol Production Overview 4.2 2014-2019 Dithiothreitol Production Market Share Analysis 4.3 2014-2019 Dithiothreitol Demand Overview 4.4 2014-2019 Dithiothreitol Supply Demand and Shortage 4.5 2014-2019 Dithiothreitol Import Export Consumption 4.6 2014-2019 Dithiothreitol Cost Price Production Value Gross Margin Chapter Five Asia Dithiothreitol Key Manufacturers Analysis 5.1 Company A 5.1.1 Company Profile 5.1.2 Product Picture and Specification 5.1.3 Product Application Analysis 5.1.4 Capacity Production Price Cost Production Value 5.1.5 Contact Information 5.2 Company B 5.2.1 Company Profile 5.2.2 Product Picture and Specification 5.2.3 Product Application Analysis 5.2.4 Capacity Production Price Cost Production Value 5.2.5 Contact Information 5.3 Company C 5.3.1 Company Profile 5.3.2 Product Picture and Specification 5.3.3 Product Application Analysis 5.3.4 Capacity Production Price Cost Production Value 5.3.5 Contact Information 5.4 Company D 5.4.1 Company Profile 5.4.2 Product Picture and Specification 5.4.3 Product Application Analysis 5.4.4 Capacity Production Price Cost Production Value 5.4.5 Contact Information Chapter Six Asia Dithiothreitol Industry Development Trend 6.1 2019-2023 Dithiothreitol Production Overview 6.2 2019-2023 Dithiothreitol Production Market Share Analysis 6.3 2019-2023 Dithiothreitol Demand Overview 6.4 2019-2023 Dithiothreitol Supply Demand and Shortage 6.5 2019-2023 Dithiothreitol Import Export Consumption 6.6 2019-2023 Dithiothreitol Cost Price Production Value Gross Margin Part III North American Dithiothreitol Industry (The Report Company Including the Below Listed But Not All) Chapter Seven North American Dithiothreitol Market Analysis 7.1 North American Dithiothreitol Product Development History 7.2 North American Dithiothreitol Competitive Landscape Analysis 7.3 North American Dithiothreitol Market Development Trend Chapter Eight 2014-2019 North American Dithiothreitol Productions Supply Sales Demand Market Status and Forecast 8.1 2014-2019 Dithiothreitol Production Overview 8.2 2014-2019 Dithiothreitol Production Market Share Analysis 8.3 2014-2019 Dithiothreitol Demand Overview 8.4 2014-2019 Dithiothreitol Supply Demand and Shortage 8.5 2014-2019 Dithiothreitol Import Export Consumption 8.6 2014-2019 Dithiothreitol Cost Price Production Value Gross Margin Chapter Nine North American Dithiothreitol Key Manufacturers Analysis 9.1 Company A 9.1.1 Company Profile 9.1.2 Product Picture and Specification 9.1.3 Product Application Analysis 9.1.4 Capacity Production Price Cost Production Value 9.1.5 Contact Information 9.2 Company B 9.2.1 Company Profile 9.2.2 Product Picture and Specification 9.2.3 Product Application Analysis 9.2.4 Capacity Production Price Cost Production Value 9.2.5 Contact Information Chapter Ten North American Dithiothreitol Industry Development Trend 10.1 2019-2023 Dithiothreitol Production Overview 10.2 2019-2023 Dithiothreitol Production Market Share Analysis 10.3 2019-2023 Dithiothreitol Demand Overview 10.4 2019-2023 Dithiothreitol Supply Demand and Shortage 10.5 2019-2023 Dithiothreitol Import Export Consumption 10.6 2019-2023 Dithiothreitol Cost Price Production Value Gross Margin Part IV Europe Dithiothreitol Industry Analysis (The Report Company Including the Below Listed But Not All) Chapter Eleven Europe Dithiothreitol Market Analysis 11.1 Europe Dithiothreitol Product Development History 11.2 Europe Dithiothreitol Competitive Landscape Analysis 11.3 Europe Dithiothreitol Market Development Trend Chapter Twelve 2014-2019 Europe Dithiothreitol Productions Supply Sales Demand Market Status and Forecast 12.1 2014-2019 Dithiothreitol Production Overview 12.2 2014-2019 Dithiothreitol Production Market Share Analysis 12.3 2014-2019 Dithiothreitol Demand Overview 12.4 2014-2019 Dithiothreitol Supply Demand and Shortage 12.5 2014-2019 Dithiothreitol Import Export Consumption 12.6 2014-2019 Dithiothreitol Cost Price Production Value Gross Margin Chapter Thirteen Europe Dithiothreitol Key Manufacturers Analysis 13.1 Company A 13.1.1 Company Profile 13.1.2 Product Picture and Specification 13.1.3 Product Application Analysis 13.1.4 Capacity Production Price Cost Production Value 13.1.5 Contact Information 13.2 Company B 13.2.1 Company Profile 13.2.2 Product Picture and Specification 13.2.3 Product Application Analysis 13.2.4 Capacity Production Price Cost Production Value 13.2.5 Contact Information Chapter Fourteen Europe Dithiothreitol Industry Development Trend 14.1 2019-2023 Dithiothreitol Production Overview 14.2 2019-2023 Dithiothreitol Production Market Share Analysis 14.3 2019-2023 Dithiothreitol Demand Overview 14.4 2019-2023 Dithiothreitol Supply Demand and Shortage 14.5 2019-2023 Dithiothreitol Import Export Consumption 14.6 2019-2023 Dithiothreitol Cost Price Production Value Gross Margin Part V Dithiothreitol Marketing Channels and Investment Feasibility Chapter Fifteen Dithiothreitol Marketing Channels Development Proposals Analysis 15.1 Dithiothreitol Marketing Channels Status 15.2 Dithiothreitol Marketing Channels Characteristic 15.3 Dithiothreitol Marketing Channels Development Trend 15.2 New Firms Enter Market Strategy 15.3 New Project Investment Proposals Chapter Sixteen Development Environmental Analysis 16.1 China Macroeconomic Environment Analysis 16.2 European Economic Environmental Analysis 16.3 United States Economic Environmental Analysis 16.4 Japan Economic Environmental Analysis 16.5 Global Economic Environmental Analysis Chapter Seventeen Dithiothreitol New Project Investment Feasibility Analysis 17.1 Dithiothreitol Market Analysis 17.2 Dithiothreitol Project SWOT Analysis 17.3 Dithiothreitol New Project Investment Feasibility Analysis Part VI Global Dithiothreitol Industry Conclusions Chapter Eighteen 2014-2019 Global Dithiothreitol Productions Supply Sales Demand Market Status and Forecast 18.1 2014-2019 Dithiothreitol Production Overview 18.2 2014-2019 Dithiothreitol Production Market Share Analysis 18.3 2014-2019 Dithiothreitol Demand Overview 18.4 2014-2019 Dithiothreitol Supply Demand and Shortage 18.5 2014-2019 Dithiothreitol Import Export Consumption 18.6 2014-2019 Dithiothreitol Cost Price Production Value Gross Margin Chapter Nineteen Global Dithiothreitol Industry Development Trend 19.1 2019-2023 Dithiothreitol Production Overview 19.2 2019-2023 Dithiothreitol Production Market Share Analysis 19.3 2019-2023 Dithiothreitol Demand Overview 19.4 2019-2023 Dithiothreitol Supply Demand and Shortage 19.5 2019-2023 Dithiothreitol Import Export Consumption 19.6 2019-2023 Dithiothreitol Cost Price Production Value Gross Margin Chapter Twenty Global Dithiothreitol Industry Research Conclusions
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