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Published: Apr, 2018 | Pages:
110 | Publisher: RNCOS
Industry: Healthcare | Report Format: Electronic (PDF)
Global Antibody Drug Conjugate Drug Sales Market is estimated to grow at a substantial CAGR in the forecast period as the scope, product types, and its applications are increasing across the globe. Antibody-drug conjugates or ADCs imply an important class of extremely potent biopharmaceutical drugs designed as a targeted therapy for the treatment of cancer. The factors that propel the growth of the Antibody Drug Conjugate Drug Sales Market include advancement in the linking technologies, cancer epidemics, increasing demand for antibody drug conjugates, and growing efforts toward patent protection. On the other hand, there are factors that may hamper the growth of the market including high production cost, lack of experienced manufacturers, and regulatory trials. Antibody Drug Conjugate Drug Sales Market may be explored by type, product type, technology, applications, end users, and geography. Antibody Drug Conjugate Drug Sales Market may be explored by Type as Linker, and Monoclonal Antibodies. Antibody Drug Conjugate Drug Sales Market may be explored by product type as Kadcyla, Adcertis. Antibody Drug Conjugate Drug Sales Market may be explored by technology as Immunomedics Technology, and Immunogen Technology. Antibody Drug Conjugate Drug Sales Market could be explored based on applications as Lymphoma, and Leukemia. The “Leukemia” segment led the Antibody Drug Conjugate Drug Sales Market in 2016 and is anticipated to maintain its dominance by 2023. Leukemia may be further explored as Chronic Myeloid Leukemia (CML), Acute Myeloid Leukemia (AML), Chronic Lymphocytic Leukemia (CLL), and Acute Lymphocytic Leukemia (ALL). Antibody Drug Conjugate Drug Sales Market may be explored by end user as Biotechnology Companies, and Pharmaceutical companies. Antibody Drug Conjugate Drug Sales Market is categorized based on geography into North America, Latin America, Japan, Middle East and Africa, Western Europe, Asia Pacific, and Eastern Europe. North America accounted for the major share of the Antibody Drug Conjugate Drug Sales Market Size in 2016 and will continue to lead in the forecast period. The factors that could be attributed to the growth could include advancement in manufacturing processes, technological innovations, and involvement of nanotechnology for developing Antibody Drug Conjugates (ADC). The key players contributing to the robust growth of the Antibody Drug Conjugate Drug Sales Market comprise Concortis Biotherapeutics, Bayer AG, Immunomedics, Inc., F. Hoffman-La Roche Ltd., NBE-Therapeutics, Immunogen, Inc., Pfizer Inc., Oxford Biotherapeutic’s, Takeda Pharmaceutical Company Limited, and Seattle Genetics, Inc. The leading companies are taking up partnerships, mergers and acquisitions, and joint ventures in order to boost the inorganic growth of the industry. Antibody Drug Conjugates are the fastest growing class of oncology therapeutics. These are monoclonal antibody based therapies which have achieved great success in the field of cancer treatment, primarily when used with cytotoxic drugs. ADC is a class of therapeutics which harnesses the antigen-selectivity of monoclonal antibodies to deliver the highly potent cytotoxic drugs to antigen expressing tumor cells. The use of monoclonal antibody directed delivery confers a therapeutic index to highly potent cytotoxic drugs, increasing both the efficacy and safety of therapy. Such novel anti-cancer drugs are being used these days to target cancers, while minimizing the exposure of healthy tissue. The recent approval of four ADCs in the global market and a strong pipeline of such drugs, highlight the potential for new therapeutic innovations in this industry. According to the RNCOS report entitled “Global Antibody Drug Conjugate Drug Sales, Pipeline Analysis (By Phase, Linker, Technology, and Indication) & Market Forecast to 2023”, the Global Antibody Drug Conjugates Market is anticipated to witness a double digit growth during 2017-2023. The report provides information about the current and future market scenario of the Global ADCs Market. The report also highlights the major drivers, such as increasing incidences of cancer and advances in linking technologies, for the Global Antibody Drug Conjugates Market. Furthermore, the report also gives information related to the commercially available ADCs such as ADCETRIS, Kadcyla, Mylotarg and Besponsa. Moreover, few hindrances, such as high cost of production cost, lack of experienced manufacturers and regulatory challenges, which are slowing down the growth of the Global ADCs Market, have also been mentioned in the report. In addition, the report also highlights various trends and developments taking place in this market. Furthermore, in this report, we have structured the information regarding ADCs at various stages of clinical development that are under research or in collaboration, and those individually being developed by companies. The pipeline chapter provides in depth analysis of ADCs of companies as well as research organizations by clinical phase, indications for which they are being developed, type of linker, drugs, and technology. Additionally, the study provides all-inclusive current analysis of various ADCs in advanced as well as early stages of development. Moreover, our report places an emphasis on the strategic alliances that can impact industry’s growth. The prominent players in Global Antibody Drug Conjugates Market have been discussed in the last section of the report. A brief business overview and financial information about each of these players has been provided, along with their product portfolios, product pipeline and recent developments. Overall, the research contains exhaustive information that will help clients in formulating market strategies and assessing opportunity areas in the Global Antibody Drug Conjugates Market.
Table Of Content
1. Analyst View
2. Research Methodology
3. Antibody Drug Conjugate (ADC) - An Introduction
4. Global Antibody Drug Conjugates Market Outlook to 2023
5. Commercialized Antibody Drug Conjugates
5.1 ADCETRIS
5.2 Kadcyla
5.3 Mylotarg
5.4 Besponsa
6. Antibody Drug Conjugates Pipeline Analysis
6.1 By Companies
6.1.1 By Clinical Phase
6.1.2 By Indication
6.1.3 By Drug
6.1.4 By Type of Linker
6.1.5 By Technology
6.2 By Research Organizations
6.2.1 By Phase
6.2.2 By Indication
6.2.3 By Drug
6.2.4 By Type of Linker
6.2.5 By Technology
7. Drivers and Challenges
7.1 Drivers
7.1.1 Rising Global Cancer Epidemics
7.1.2 Advances in Linking Technologies Re-Instills Hope in ADC
7.1.3 Efforts towards Patent Protection to Drive ADC Market
7.1.4 Increasing Demand for Antibody Drug Conjugates
7.2 Challenges
7.2.1 Production Hurdles and Cost
7.2.2 Inadequacy of Experienced Manufacturers
7.2.3 Regulatory Challenges
8. Major Potential Antibody Drug Conjugates in Pipeline
8.1 By Companies
8.1.1 Glembatumumab Vedotin Therapeutics/CDX-011 - Celldex
8.1.2 Coltuximab Ravtansine/SAR3419 - ImmunoGen Inc.
8.1.3 Indatuximab Ravtansine/BT-062 – Biotest AG
8.1.4 Anti-PSMA ADC Therapeutic - Progenics Pharmaceuticals
8.1.5 Polatuzumab Vedotin/RG7596 - F. Hoffman-La Roche Ltd.
8.1.6 DMUC-4064A/RG7882 - F. Hoffman-La Roche Ltd.
8.1.7 Mirvetuximab Soravtansine/IMGN853 - ImmunoGen Inc.
8.2 By Research Organizations
8.2.1 SGM-101 - SurgiMab in Collaboration with Center for Human Drug Research, Netherlands
8.2.2 MOC31-PE - Creative Biolabs in Collaboration with Oslo University Hospital
9. Trends and Developments
9.1 ADC at the Forefront of Treating Hematological Malignancies
9.2 ADCs Proving Advantageous for Breast Cancer Patients
10. Strategic Alliances in the Global Antibody Drug Conjugates Industry
11. Competitive Assessment
11.1 Seattle Genetics, Inc.
11.2 F. Hoffman-La Roche Ltd.
11.3 Pfizer Inc.
11.4 ImmunoGen, Inc.
11.5 Bayer AG
11.6 Takeda Pharmaceutical Company Limited
11.7 Immunomedics, Inc.
11.8 Oxford BioTherapeutics
11.9 Concortis Biotherapeutics
11.10 NBE-Therapeutics
List of Tables: Table 5-1: Global - Incidence of Hodgkin Lymphoma, 2012, 2015, 2020, & 2025 Table 5-2: Global - Incidence of Non-Hodgkin Lymphoma, 2012, 2015, 2020, & 2025 Table 5-3: Major Ongoing Trials for ADCETRIS Table 5-4: Global - Incidence of Breast Cancer, 2012, 2015, 2020, & 2025 Table 5-5: Major Ongoing Trials for Kadcyla Table 5-6: Major Ongoing Trials for Mylotarg Table 5-7: Major Ongoing Trials for Besponsa Table 6-1: Global - ADC Pipeline of Companies Table 6-2: Global - ADC Pipeline of Research Organization Table 10-1: Major Strategic Alliances in the Global Antibody Drug Conjugates Industry (2014-2017) Table 11-1: Seattle Genetics, Inc. - Key Financials (Million US$), 2014-2016 Table 11-2: Seattle Genetics, Inc. - ADC Product Portfolio Table 11-3: Seattle Genetics, Inc. - ADCs in Pipeline Table 11-4: F. Hoffman-La Roche Ltd. - Key Financials (Million US$), 2014-2016 Table 11-5: F. Hoffman-La Roche Ltd. - ADC Product Portfolio Table 11-6: F. Hoffman-La Roche Ltd. - ADCs in Pipeline Table 11-7: Pfizer Inc. - Key Financials (Million US$), 2014-2016 Table 11-8: Pfizer Inc. - ADC Product Portfolio Table 11-9: Pfizer Inc. - ADCs in Pipeline Table 11-10: ImmunoGen, Inc. - Key Financials (Million US$), 2014-2016 Table 11-11: ImmunoGen, Inc. - ADCs in Pipeline Table 11-12: Bayer AG - Key Financials (Million US$), 2014-2016 Table 11-13: Bayer AG - ADCs in Pipeline Table 11-14: Takeda Pharmaceutical Company Limited - Key Financials (Million US$), 2014-2016 Table 11-15: Takeda Pharmaceutical Company Limited - ADCs in Pipeline Table 11-16: Immunomedics, Inc. - Key Financials (Million US$), 2015-2017 Table 11-17: Immunomedics, Inc. - ADCs in Pipeline Table 11-18: Oxford BioTherapeutics - ADCs in Pipeline Table 11-19: Concortis Biotherapeutics - ADCs in Pipeline Table 11-20: NBE-Therapeutics - ADCs in Pipeline List of Figures: Figure 3-1: ADC - Mechanism of Action Figure 4-1: Global - ADC Market (Billion US$), 2016, 2017 & 2023 Figure 5-1: Global - ADCETRIS Sales (Million US$), 2016 & 2017 Figure 5-2: Global - Kadcyla Sales (Million US$), 2016 & 2017 Figure 6-1: Global - ADCs Pipeline by Developing Organizations (%), 2017 Figure 6-2: Global - ADC Pipeline of Companies by Clinical Phase (%), 2017 Figure 6-3: Global - ADC Pipeline of Companies by Indication (%), 2017 Figure 6-4: Global - ADC Pipeline of Companies by Drug (%), 2017 Figure 6-5: Global - ADC Pipeline of Companies by Type of Linker (%), 2017 Figure 6-6: Global - ADC Pipeline of Companies by Technology (%), 2017 Figure 6-7: Global - ADC Pipeline of Research Organization by Clinical Phase (%), 2017 Figure 6-8: Global - ADC Pipeline of Research Organization by Indication (%), 2017 Figure 6-9: Global - ADC Pipeline of Research Organization by Drug (%), 2017 Figure 6-10: Global - ADC Pipeline of Research Organization by Type of Linker (%), 2017 Figure 6-11: Global - ADC Pipeline of Research Organization by Technology (%), 2017 Figure 11-1: F. Hoffman-La Roche Ltd. - Group Sales Breakup by Business Segments (%), 2016 Figure 11-2: Pfizer Inc. - Revenue Breakup by Business Segments (%), 2016 Figure 11-3: Pfizer Inc. - Revenue Breakup by Geography (%), 2016 Figure 11-4: Bayer AG - Sales Breakup by Business Segments (%), 2016 Figure 11-5: Bayer AG - Net Sales Breakup by Geography (%), 2016 Figure 11-6: Takeda Pharmaceutical Company Limited - Ethical Drugs Revenue Breakup by Geography (%), 2016 Figure 11-7: Immunomedics, Inc. - Revenue Breakup by Geography (%), 2017
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