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Biological Implants

Published: Apr, 2015 | Pages: 576 | Publisher: RESEARCH IMPACT TECHNOLOGIES
Industry: Biotechnology | Report Format: Electronic (PDF)

This report on Biological Implants analyzes the global market for biological implant procedures. The total biological implants market is analyzed by tissue/muscle; origin, and mode of administration at global level and for each of the geographic regions - North America, Europe, Asia-Pacific and Rest of World. The biological implants market is segmented by Tissue/Muscle into Soft Tissue, Orthopedic, Cardiovascular and Other (includes Dental, Ophthalmic, and Urologic); by Origin into Allograft, and Xenograft; and by Mode of Administration into Injectable and Surgical. Business profiles of 25 major companies are discussed in the report. The report serves as a guide to global biological implants industry covering more 140 companies that are engaged in biological implants' processing, R&D, storage, banking, discovery, testing and supply of products and services. Major Contract Research Organizations and Universities serving the industry are also covered in the Corporate Directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, mergers and acquisitions, ethical issues, regulatory affairs, and other areas of concern is also covered in the report. Compilation of Worldwide Patents and Research related to biological implants is also provided. Estimations and Predictions are graphically illustrated by geographic regions by 117 exclusive exhibits.
 Table of Content
1. SCOPE AND METHODOLOGY	1
2. REPORT SYNOPSIS	3
2.1 Introduction	3
Biological Implants – A Revolutionary Human Repair Technique	3
Medical Implants	3
An Overview of Medical Implants	3
History of Implants	4
The Need for a Better Implant	4
Naturally Derived Implants	4
Orbital Implants and Artificial Eyes	5
Artificial Skin	6
Hip Replacement	7
Tissues	7
Animal Tissues	8
Plant Tissues	9
Definitions	9
Implant	9
Transplant	9
Explant	9
Types of Implants	9
Artificial Implants	9
Prothesis	10
Bio-implant	10
Disadvantages of Artificial implants	10
Biological Implants	10
Tissue Engineering	10
2.2 Segmentation of Biological Implants	11
Exhibit 1. Segmentation of Global Biological Implants Market by Tissue/Muscle, by Origin and  by Mode of Administration	11
2.2 Biological Implants - Global Market Analysis	12
Exhibit 2. Biological Implants – Global Market Estimations & Predictions (2005 – 2020) in US$ Million	12
Exhibit 3. List of Major Global Biological Implant Companies	13
3. MARKET DYNAMICS	14
3.1Global Market Overview	14
3.2 Global Medical Implants Market	14
Exhibit 4. Medical Implants – Global Market Estimations & Predictions (2005 - 2020) in US$ Billion	15
3.2.1 Spinal Implants	16
Exhibit 5. Spinal Implants – Global Market Estimations & Predictions (2005 - 2020) for Implants in North America, Europe, Asia, Canada and Rest of World in US$ Million	16
Exhibit 6. Spinal Implants – Global Market Shares (2010, 2015 & 2020) for Implants in North America, Europe, Asia-Pacific, Canada and Rest of World	17
3.2.2 Orthopedic Implants	18
Exhibit 7. Orthopedic Implants – Global Market Estimations & Predictions (2005 - 2020) for North America, Europe, Asia-Pacific, and Rest of World in US$ Million	18
Exhibit 8. Orthopedic Implants – Global Market Shares (2010, 2015 & 2020) for North America, Europe, Asia-Pacific, and Rest of World	19
3.2.3 Cardiovascular Implants	20
Exhibit 9. Cardiovascular Implants – Global Market Estimations & Predictions (2005 - 2020) for Cardiovascular Implants in North America, Europe, Asia, and Rest of World in US$ Million	20
Exhibit 10. Cardiovascular Implants – Global Market Shares (2010, 2015 & 2020) for Cardiovascular Implants in North America, Europe, Asia–Pacific, and Rest of World	21
3.2.4 Dental Implants	22
Exhibit 11. Dental Implants – Global Market Estimations & Predictions (2005 - 2020) for Dental Implants in North America, Europe, Asia, and Rest of World in US$ Million	22
Exhibit 12. Dental Implants – Global Market Shares (2010, 2015 & 2020) for Dental Implants in North America, Europe, Asia – Pacific, and Rest of World	23
Biological Implants	24
3.3 Global Biological Implants Market	24
Exhibit 13. Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific, and Rest of World in US$ Million	24
Exhibit 14. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	25
3.4 North American Biological Implants Market	26
Exhibit 15. Biological Implants –North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	26
Exhibit 16. Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	27
3.4 (I) United States Biological Implants Market	27
3.4 (II) Canadian Biological Implants Market	27
Exhibit 17. List of Major Biological Implants Companies in North America	27
3.5 European Biological Implants Market	29
Exhibit 18. Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	29
Exhibit 19. Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	30
3.5 (I) German Biological Implants Market	30
3.5 (II) United Kingdom Biological Implants Market	30
3.5 (III) French Biological Implants Market	30
3.5 (IV) Swiss Biological Implants Market	30
3.5 (V) Russian Biological Implants Market	31
Exhibit 20. List of Major Biological Implants Companies in Europe	31
3.6 Asia-Pacific Biological Implants Market	32
Exhibit 21. Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	32
Exhibit 22. Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific	33
3.6 (I) Australian Biological Implants Market	33
3.6 (II) Japanese Biological Implants Market	33
3.6 (III) Chinese Biological Implants Market	33
3.6 (IV) Indian Biological Implants Market	33
3.6 (V) South Korean Biological Implants Market	34
Exhibit 23. List of Major Biological Implants Companies in Asia-Pacific	34
3.7 Rest of World Biological Implants Market	35
Exhibit 24. Biological Implants – Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	35
Exhibit 25. Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	36
3.7 (I) Israeli Biological Implants Market	36
3.7 (II) Brazilian Biological Implants Market	36
3.7 (III) South African Biological Implants Market	36
3.8 Market Trends	37
3.9 Product Trends	38
Research and Development	38
Neovascularisation Promoting Membrane for Biological Implants	38
Biological Implants of Semipermeable Amphiphilic Membranes	38
Artificial Tissue Systems	39
Stem Cells in Biological Implants	39
Overview	39
Various Animal Models Used and Methods Followed	39
The Outcome	39
Analysis	40
The Journey of Embryonic Stem Cells from Fundamental Biology to Medicine Field	40
Application of Umbilical Cord Lining Cells as Therapeutic Bioimplants for Metabolic Disorders	40
Drug Delivery and Smart Biological Implants	40
Tissue Engineered Biological Implants	41
Biological Implants for Treatment of Vocal Fold Disorders	44
Systemic Inhibition of Tumor Growth using Biological Implants	45
Process of Secretion and Expression of TSP-2 Using Polymer-Cell Grafts in Vivo	45
Inhibition of Tumor Growth in Mice Containing TSP-2-secreting Bioimplants	46
Inhibition of Tumor Angiogenesis in Mice Containing TSP-2-secreted Bioimplants	46
Surgery for Valvular Heart Disease	47
RVOT Reconstruction	50
Bovine Valved Venous Xenografts for RVOT Reconstruction	50
Alloplastic Implants for the Treatment of Stress Urinary Incontinence	51
Repair of Cartilage Lesions	51
Repair of Cartilage Lesions Using Biological Implants - A Comparative Histological and Biomechanical Study in Goats	51
Cryopreservation of Human Ovarian Tissues	52
CXC Technology: ADAPT (Advanced Tissue Process)	52
Celxcel – Patches	52
Clinical Trials	53
Man Gets Teeth from Shoulder	53
Implantation of Esterified Hyaluronic Acid in Microdissected Reinke's Space after Vocal Fold Microsurgery	54
Healing of Brain and Bones	54
Saving Brain and Spines	55
The Perfect Knee	55
Get the Smile Back on Your Face	56
Mending Broken Hearts	56
Biological Implants in Sports Medicine	57
Allografts in Sports	57
Ligament Reconstruction	57
Meniscal Allograft	57
Osteochondral Allograft	57
Transplantation Genetics	58
Acceptance of Biological Implants	59
Biphasic Implants	60
Preparation of a Biphasic Scaffold	60
Devising Biological Implants for Healing of Joint Disorders	60
Biomaterials	61
The Construction of New Body Parts	61
Orthopedic Biomaterials	61
Heart Valve Biomaterials	62
Risk of Infection, Off – Label Use and Safety	63
Exhibit 26. Different Processes Used for Preservation of Allografts and Xenografts	64
Ethical Issues Concerning Biological Implants	64
Moral Issue and Balancing concept	64
Animal Rights	65
“Speciesism”	65
Rights	65
Objectivity	66
Practical Issue	66
Animal-to-Human Transplantation	67
3.10 Company Profiles - Major Players in Biological Implants Market	75
Aastrom Biosciences, Inc. (USA)	75
Admedus Ltd. (Australia)	77
ADODERM GmbH (Germany)	78
Alphatec Spine, Inc. (USA)	79
Anteis SA (Switzerland)	80
Arthro Kinetics Plc (UK)	82
Asterand Plc (UK)	83
AutoTissue GmbH (Germany)	84
Baxter Healthcare Corporation (USA)	85
Biopolymer GmbH & Co. KG (Germany)	86
BioTissue Technologies AG (Germany)	87
CR Bard, Inc. (USA)	88
CryoLife®, Inc. (USA)	89
DePuy Orthopaedics, Inc. (USA)	91
Edwards Lifesciences Corporation (USA)	92
Exactech, Inc. (USA)	95
Fidia Farmaceutici SpA (Italy)	96
Inion OY (Finland)	97
Integra LifeSciences Corporation (USA)	101
IOP, Inc. (USA)	103
LifeCell Corporation (USA)	105
Maxigen Biotech, Inc. (Taiwan)	106
Medtronic, Inc. (USA)	107
NuVasive, Inc (USA)	109
Organogenesis, Inc. (USA)	110
Prollenium Medical Technologies, Inc. (USA)	110
RTI Biologics, Inc. (USA)	112
Seikagaku Corporation (Japan)	120
Stryker Corporation (USA)	121
Wright Medical Technology, Inc. (USA)	122
3.11 Major Activities in Biological Implants Market	124
Vivex Biomedical Partners with Akron Biotech	124
Valeant Pharmaceuticals Sells Filler and Toxin Assets to Galderma	124
Bioheart Seeks Partnership in South Africa	124
Medtronic Buys Stake in Covidien worth US$ 42.9 billion	125
aap Divests the aap BM to botiss	125
Zimmer Holdings to Acquire Biomet	125
Bioheart Alliances with MCT	125
CryoLife Buys Distribution Rights for ProCol® Vascular Bioprosthesis	126
Sorin Group Acquires Cannulae Manufacturing Activities from Bioengineering Laboratories	126
Integra LifeSciences Acquires Covidien’s DuraSeal Products	126
Cortec Group Acquires IOP Ophthalmics	126
LifeCell Corporation Buys Advanced Adipose Tissue Injector	127
Organogenesis Acquires Dermagraft® from Shire	127
RTI and Yankee Alliance Enters into Agreement	127
Wright Medical Group Acquires Biotech International	127
Amedica Corp., Collaborates with Kyocera Industrial Ceramics Corporation	128
Bioheart Contracts with GSCG to Offer Bioheart Therapies	128
Boston Scientific Acquires Bard Electrophysiology	128
Bioheart Inks an Agreement with Anosis for the Product Distribution in the Middle East	129
Allosource Inks Strategic Manufacturing Partnership Agreement with Humacyte	129
Bioheart Alliances with AFRIMID for the Stem Cell Product Distribution in Uganda	129
Bioheart Inks a License Agreement with Invitrx for Adipose Derived Stem Cells	130
Bard Acquires Medafor, Inc.	130
RTI Biologics Acquires Pioneer® Surgical Technology	130
NuVasive® Acquires Ohio based ANC	130
AlloSource Partners with FOCOS	131
NuVasive® Inaugurates New Office in Japan	131
Wright Medical Group Acquires BioMimetic Therapeutics Inc.	131
ReNeuron Collaborates with Cell Therapy Catapult on New Cell Manufacturing Technologies	132
Alphatec Spine Acquires Phygen LLC	132
Bioheart Partners with Stemlogix	132
AlloSource Inaugurates New Headquarter Campus	133
Stemgent Procures Rights on Asterand’s Human Tissue Business	133
AlloSource Partners with LifeGift	134
Johnson & Johnson Acquires Synthes to Build up Orthopedics Business Worldwide	134
CryoLife Buys Hemosphere	134
Premier Healthcare Alliance Grants Supply Contract to Advanced Biologics for OsteoAMP® Product Line	134
Abbott Inks Partnership Agreement with St. Jude Medical	135
Sanofi Acquires Pluromed	135
Kuros and Synthes Enters into Licensing and Development Agreement	136
Synovis, Now a Subsidiary of Baxter	136
MTF Enters into Partnership with CONMED/Linvatec	137
Medicis Completely Acquires Graceway	137
UK Government Takes Initiative to Develop Elite Cell Therapy Centre	137
Integra LifeSciences Acquires Ascension Orthopedics	137
AlloSource Collaborates with ARM and MDMA	138
Medtronic Takes Over Salient Surgical Technologies and PEAK Surgical	138
Extension of Contract Manufacturing Arrangements by ReNeuron with Angel Biotechnology for ReNoo1 stroke therapy	139
Arterius Ltd. Signs a New Research Collaboration	139
BioMD Adopts New Corporate Identity	139
ACT Collaborates with Roslin Cells for Commercialization of ACT's Blastomere Technology	139
Misonix Enters into Exclusive Agreement with Anika Therapeutics	140
Stryker Buys Orthovita	140
CryoLife Acquires Cardiogenesis	141
Integra LifeSciences Completes Acquisition of SeaSpine	141
Sanofi-Aventis Completes Acquisition of Genzyme Corporation	142
RTI and Alphatec Spine Enters into a Processing and Supply Agreement	142
NuVasive and AlloSource Enters into Licensing Agreement	142
Medtronic Acquires Osteotech	142
ArunA Biomedical Joins Hands with Mediatech	143
Xenogenics Completes the Acquisition of the Assets of Ideal BioStent	143
ART Raises US$ 8.5M for Biodegradable Stents	143
Zimmer Dental and RTI Biologics Signs Agreement for Dental Biologic Implants	144
VertiFlex’s Minimally Invasive Spine Reconstruction Portfolio Acquired by Exactech	144
Alphatec Spine and Parcell Spine Signs Exclusive Distribution Agreement	144
Piramal Healthcare Acquires BioSyntech Assets	145
Exactech Acquires Brighton Partners and its Proprietary Knee Replacement Technology	145
Landec Corporation Completes Acquisition of Lifecore Biomedical	145
Alphatec Holdings Acquires Scient’x Groupe	145
Merz Acquires BioForm Medical	146
Anika Therapeutics Acquires Fidia Advanced Biopolymers	146
Osteotech and Community Tissue Services (CTS) Enter into a Ten Year Tissue Supply Agreement	146
Celling Technologies Enters into Exclusive Agreement with Tissue Genesis	147
Alphatec Spine and ETEX Corporation Sign a Supply and Distribution Agreement	147
Integra LifeSciences Acquires the Assets of Innovative Spinal Technologies	148
Synovis Life Technologies Acquires the Assets of Pegasus Biologics	148
Intercytex Group Acquires Stem Cell Company, Axordia Limited	148
Medical Ventures Corp., (MEV) Renamed to Neovasc Inc., (NVC) with Two Corporate Acquisitions and US$ 8.3 Million Financing	149
Biohorizons and Osteotech Signs Distribution Agreement for Supplying Osteotech's Products to the Global Dental Market	149
Osteotech Signs Agreement with Harvest Technologies for Distribution Rights of BMAC™ System	149
Alphatec Holdings Acquires Worldwide License for Innovative Expandable Inter-body/ Vertebral Body Replacement Technology	150
Organogenesis Acquires NanoMatrix Inc	150
Integra LifeSciences Acquires IsoTis and Attain Global Leadership in Orthobiologics	150
Organogenesis Inc. Signs MoU with National Tissue Engineering Center of China	151
Tutogen Medical, Inc. Signs New Tissue Supply Agreement and Extends Existing Agreement	151
Regeneration Technologies Merges with Tutogen Medical	151
Integra Creates a New Global Leader in Orthobiologics with New Acquisition (IsoTis)	151
Osteotech Signs Tissue Supply Agreement with LifeNet Health	152
RTI Signs Distribution and Supply Agreement with Stryker Corporation	152
Tutogen Medical Signs an International Distribution Agreement with Coloplast Corporation	153
Osteotech and Novation Sign Single Source Agreement	153
IsoTis Expands Existing Private Label Agreement with AlloSource for First Generation DBM Products	153
RTI Signs Ten Year Distribution Agreement with Zimmer Holdings for New Allograft Paste Implant	153
Tutogen Medical Signs Distribution Agreement with Zimmer Holdings	154
Alphatec Holdings Acquires Technology License for Minimally Invasive Spinal Surgery Market	154
Advanced Cell Technology Buys Technology Assets of Infigen	154
NuVasive Buys Biologic Product Platform	155
License Agreements between Alphatec and Scient’x for Manufacture and Distribution of Spine Implants	155
Musculoskeletal Transplant Foundation Announces Three Year Deal with Affinergy	156
Encore Medical Acquires Cefar AB of Sweden	156
CryoLife Enters into Alliance with Bioform Medical for Development and Marketing of BioGlue®	156
Stem Cell Innovations Enters into Collaboration with ND TWente University for Assessment of Bone Forming Capability of Pluricells	157
Affinergy Signs Development Agreement with Synthes	157
Affinergy Joins Hands with DuPont for New Bio-based Materials	157
Acquisition of Exclusive Option Rights of Cell Technology by Bioheart	157
Axordia Enters into Collaboration with Lombard Medical Technologies for Developing of Therapy for Coronary Artery Disease	158
Smith & Nephew Buys OsteoBiologics Inc.	158
Alphatec Spine and OsteoBiologics Enter into an Agreement for Distribution of Spine Products	158
Bioheart Signs Agreement to Use Cleveland Clinic’s Proprietary Methods	159
Cambrex Buys Cutanogen Corporation	159
Inion Enters into Alliance with Aesculap for Distribution of its Spinal Product Range across the United States and Canada	159
Inion Enters into an Agreement with the University of Cambridge for Advancement of its Bioactive Products	159
Inion and Richard Wolf Medical Instruments Enter into Agreement for Distribution of Sports Medicine Product Range	160
International Distribution Agreement Signed by OsteoBiologics and CONMED Linvatec for Cartilage and Bone Repair Product Range	160
Millenium Biologix Enters into License Agreement Exclusively to Improve ACTES(TM)-C	160
OsteoBiologics Enters into Collaboration with Nexa Orthopedics for Surgical Extremities	160
Genzyme Acquires Verigen AG	161
CryoLife and Endologix Enter into a Development Agreement for BioFoam	161
3.12 Major Product Innovations/Launches in Biological Implants Market	162
BioHorizons Launches Novel Range of Xenograft Products	162
First Implantation of CROWN PRT™ Heart Valve of Sorin Group	162
FDA Approves Solo Smart™, the New Tissue Valve Technology Product of Sorin Group	162
Caredx and Allegheny General Hospital Initiate D-OAR Study	163
Bioheart Introduces the First Combination Stem Cell Treatment	163
Bioheart Initiates two Clinical Trials in India	163
Aastrom Buys Cell Therapy and Regenerative Medicine Business unit of Sanofi	164
Elixir Medical Announces Receipt of CE Mark Approval for Bioresorbable DESolve® 100 Novolimus Eluting Coronary Scaffold System	164
Aperion’s Z-Lig ACL Replacement Device Gains CE Mark Approval	164
Cytori Receives Patent for Wound Healing Methods Utilizing Adipose-Derived Regenerative Cells	165
Nobel Biocare Unveils the New creos™ Allograft Regenerative Solutions	165
RTI Surgical’s FortivaTM Certified by CE Mark	166
Zimmer and Allosource Introduces Bone Graft Substitute Products	166
ACell Introduces novel MatriStem® Multilayer Wound Matrix Device Solution for Difficult-to-Heal Deep Wounds	166
Zimmer Introduces Ready-to-Use Bone Graft Substitutes	166
ACell Widens Portfolio of MatriStem® Pelvic Floor Matrix Products	167
DePuy Synthes Spine Introduces Conform Sheet™	167
First implantation of Elixir Medical’s DESolve® Novolimus Eluting Coronary Scaffold System in Europe	167
Smith & Nephew Launches Advanced Bio-Composite Material for Arthroscopic Surgery Applications	168
LifeCell Corp., Launches REVOLVE™ System	168
BIOTRONIK Reports Use of First–in–Human Use of Bioabsorbable Magnesium DREAMS Scaffold	169
Allosource Introduces AlloMend™	169
Orthofix in Association with MTF Launches Trinity® ELITE™ Allograft	170
Orthofix and MTF Launches Trinity ® ELITE™ Allograft	170
Elixir's DESolve® Novolimus Eluting Bioresorbable Coronary Scaffold System Certified by CE	170
ISTO Technologies Takes Control of DeNovo ET Cartilage Repair Technology Program	171
Medical Receives European Approval Portico™ Transcatheter Aortic Heart Valve and Transfemoral Delivery System	171
Arterial Remodeling Technologies (ART) Announces First Human Use of Its Bioresorbable Stent	172
Edwards to Begin TRANSFORM Trial, for Assessing the Proprietary INTUITY Valve System	172
Scottish Medicines Consortium Acknowledges the Use of Allergan’s OZURDEX® (dexamethasone 700mcg intravitreal implant) in NHS Scotland	173
Edwards Attains FDA’s IDE for the US Clinical Trial of GLX next-generation tissue treatment platform	173
Integra LifeSciences Reinforces Spinal Product Portfolio Including a Stand-Alone, Zero-Profile Device for ALIF Procedures	173
FDA Approval for Organogenesis’ GINTUIT™	174
Bioheart Buys Rights to Ageless	174
Integra Life Sciences Launches Integra® Allograft Wedge System for Extremity Reconstruction	175
Amedica Launches Valeo® VBR, Silicon Nitride Implant	175
Signature™, BIOMET’s New Personalized Patient Care System for Partial Knee Replacements	175
Advanced Cell Technology Successfully Completes Clinical Trial of Human Embryonic Stem Cell Transplant in Stargardt Patients	176
S3V Vascular Technologies Introduces first Bioabsorbable Endovascular Drug Coated Stent "3V-Avatar"in India	176
Sanofi In-Licenses Scil Technology’s Regenerative Treatment Program	177
Jude Medical Successfully carries out First Implant in European Clinical Trial Studying Portico Transcatheter Aortic Heart Valve	177
Exactech Begins Clinical Trial for the Innovative Cartilage Regeneration Technology	178
Airspeed Equity in Association with Bioheart Launches MyoStim and Biopace Products	178
ISTO Technologies’ InQu® Bone Graft Substitute and Extender Receive CE Mark	179
Medtronic Commences a Pivotal Trial for Engager™ Transcatheter Aortic Valve Implantation System	179
StemCells Inc. Carries World’s First Neural Stem Cell Transplant in a Spinal Cord Injury Patient	180
UK Medical Launches the First Ever Biodegradable Esophageal Stent	180
Curasan AG Receives European Approval for Cerasorb ® Foam	180
RTI Biologics Introduces New Meniscus Allograft Instrumentation	180
RTI Biologics Releases the BioAdapt™ DBM Foam	180
St. Jude Medica Announces First Successful Implant of Portico Transcatheter Heart valve	181
Wright Medical Introduces INBONE® II Total Ankle Replacement System	181
Urinary Incontinence Research Employing Celution® System Receives Approval in Japan	182
Tornier Introduces BioFiber® Surgical Mesh for Tendon Repair	182
Orthovita Unveils the Aliquot™ Directional Bone Tamp Device	183
CryoLife Introduces BioGlue®, a Novel Surgical Adhesive across Japan	183
US Patent to Cytori for Methods of Making Enhanced, Autologous Fat Grafts	183
Orthovita Introduces Vitoss BA2X, a Non-Structural Bone Void Filler	184
Cytori Receives Patent for Cell-Enriched Fat Grafting	184
Integra LifeSciences Launches Allograft Cancellous Sponge	185
Integra LifeSciences Launches Advanced Orthobiologics for Extremity Reconstruction	185
Abbott Announces the CE Marking on ABSORB in Europe, World's First Drug Eluting Bioresorbable Vascular Scaffold	186
Aperion Biologics Receives Project Grant for Therapeutic Discovery	186
NJ and MTF Edison Launches the Largest Acellular Dermal Allografts for Abdominal Wall Repair	186
Wright Medical Group Launches the XPANSION® Micrografting System	187
RTI Biologics Introduces Two Biologic Implants	187
Medicis’ Restylane® and Perlane® with Lidocaine Receives Approval	188
First Time Terminally Sterilized Allograft Dermis Successful in Reducing Condition Symptoms	188
Organogenesis Submits PMA for CelTx™ for FDA Approval	189
CONMED Linvatec Launches Matryx® Biocomposite Interference Screws of Various Sizes for PCL and ACL Reconstructions	189
CONMED Linvatec Unveils Bullseye™ Anatomic Cruciate Reconstruction System	190
LifeNet Health Introduces Vertigraft Cervical Bio-Implant with Preservon Technology	190
Integra LifeSciences Extends Accell Evo3 Product Line	191
Inion Reinforces Product Range in Spine and Specialty Orthopedics	191
Exactech Develops New Biological Implants for Knee Replacement Surgeries	191
RTI Biologics and Entrigue Surgical Develop Biological Implants for ENT Patients	192
IOP Introduces Advanced Amniotic Membrane Technology, Ambio5™	192
RTI Unveils CopiOs®, the Proprietary Bovine Pericardium Membrane Implant in the Dental market	192
CryoLife to Distribute Hemostase MPH® through Sorin Group Canada	193
Osteotech's Plexur M™ Biocomposite Approved by FDA for Spinal Applications	193
Exactech Introduces Advanced Novation® Crown Cup Acetabular System	193
CE Mark for CryoLife’s BioGlue® Surgical Adhesive	194
IGAKI-TAMAI’s Bioabsorbable Stent Gains CE Mark Status for Peripheral Artery	194
RTI Introduces New BioCleanse® Meniscus	194
Mentor Launches New NeoForm™ Dermis for Breast Reconstruction	194
LifeCell Corporation Receives 510(k) Clearance for New Soft Tissue Repair Product	195
Inion Granted with US Patent for Bioactive Materials Technology	195
Japanese Ministry Endorses Alphatec’s NOVEL Titanium Product Family	195
FDA Approval to Exactech for Distribution of Equinox® Reverse Shoulder	196
U.S. FDA Grants 510(k) Clearance to Osteotech for Plexur™ P	196
Inion Product Range of BMI Widens with the Approval of ANCHRON™ in Europe	196
University of Rochester and StemCapture Unveil an Anticancer Stem Cell Implant Device	197
Pegasus Biologics’ Wound Dressing Receives FDA approval	197
Exactech Gains FDA Clearance for DBM with Bone Chips, OptecureTM +CCC	197
Bone Growth Stimulator – New Product of Alphatec Holdings	197
Exactech Adds Cemented Stem to its Hip System	198
Avecia Given £1m Grant to Develop Bioprocessing Technology for Generating Synthetic Skin for Burn Victims	198
Patent Licensing Agreement Signed between Bioheart Inc and Tricardia	198
Inion’s Novel Bioactive Technology Granted with US Patent	199
Pegasus Launches OrthADAPT™ Bioimplant - a Revolutionary New Biologic Scaffold for Orthopedic Soft Tissue Reinforcement	199
Inion Launches Biodegradable Spinal Implant in the EU	199
Affinergy Awarded SBIR Grant for Research on Medical Device Materials	199
3.12 Analysis by Tissue/Muscle	200
Exhibit 27. Biological Implants - Global Market Estimations & Predictions (2005 - 2020) by Tissue/Muscle for Orthopedic, Soft Tissue, Cardiovascular and Other in US$ Million	200
Exhibit 28. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Tissue/Muscle for Orthopedic, Soft Tissue, Cardiovascular and Other	201
3.12.1 Orthopedic	202
3.12.1.1 Global Orthopedic Biological Implants Market	202
Exhibit 29. Orthopedic Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	203
Exhibit 30. Orthopedic Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	204
3.12.1.2 North American Orthopedic Biological Implants Market	205
Exhibit 31. Orthopedic Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	205
Exhibit 32. Orthopedic Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	206
3.12.1.3 European Orthopedic Biological Implants Market	207
Exhibit 33. Orthopedic Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	207
Exhibit 34. Orthopedic Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	208
3.12.1.4 Asia-Pacific Orthopedic Biological Implants Market	209
Exhibit 35. Orthopedic Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	209
Exhibit 36. Orthopedic Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific (Graphical Representation Included)	210
3.12.1.5 Rest of World Orthopedic Biological Implants Market	211
Exhibit 37. Orthopedic Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	211
Exhibit 38. Orthopedic Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	212
3.12.2 Soft Tissue	213
3.12.2.1 Global Soft Tissue Biological Implants Market	214
Exhibit 39. Soft Tissue Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	214
Exhibit 40. Soft Tissue Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	215
3.12.2.2 North American Soft Tissue Biological Implants Market	216
Exhibit 41. Soft Tissue Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	216
Exhibit 42. Soft Tissue Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	217
3.12.2.3 European Soft Tissue Biological Implants Market	218
Exhibit 43. Soft Tissue Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	218
Exhibit 44. Soft Tissue Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	219
3.12.2.4 Asia-Pacific Soft Tissue Biological Implants Market	220
Exhibit 45. Soft Tissue Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	220
Exhibit 46. Soft Tissue Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific	221
3.12.2.5 Rest of World Soft Tissue Biological Implants Market	222
Exhibit 47. Soft Tissue Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	222
Exhibit 48. Soft Tissue Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	223
3.12.3 Cardiovascular	224
3.12.3.1 Global Cardiovascular Biological Implants Market	224
Exhibit 49. Cardiovascular Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	224
Exhibit 50. Cardiovascular Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	225
3.12.3.2 North American Cardiovascular Biological Implants Market	226
Exhibit 51. Cardiovascular Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	226
Exhibit 52. Cardiovascular Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	227
3.12.3.3 European Cardiovascular Biological Implants Market	228
Exhibit 53. Cardiovascular Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	228
Exhibit 54. Cardiovascular Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	229
3.12.3.4 Asia-Pacific Cardiovascular Biological Implants Market	230
Exhibit 55. Cardiovascular Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	230
Exhibit 56. Cardiovascular Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific	231
3.12.3.5 Rest of World Cardiovascular Biological Implants Market	232
Exhibit 57. Cardiovascular Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	232
Exhibit 58. Cardiovascular Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	233
3.12.4 Other (Dental, Ophthalmic and Urologic)	234
3.12.4.1 Global Other Tissue/Muscle Biological Implants Market	234
Exhibit 59. Other Tissue/Muscle Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	234
Exhibit 60. Other Tissue/Muscle Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	235
3.12.4.2 North American Other Tissue/Muscle Biological Implants Market	236
Exhibit 61. Other Tissue/Muscle Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	236
Exhibit 62. Other Tissue/Muscle Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	237
3.12.4.3 European Other Tissue/Muscle Biological Implants Market	238
Exhibit 63. Other Tissue/Muscle Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	238
Exhibit 64. Other Tissue/Muscle Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	239
3.12.4.4 Asia-Pacific Other Tissue/Muscle Biological Implants Market	240
Exhibit 65. Other Tissue/Muscle Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	240
Exhibit 66. Other Tissue/Muscle Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific	241
3.12.4.4.5 Rest of World Other Tissue/Muscle Biological Implants Market	242
Exhibit 67. Other Tissue/Muscle Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	242
Exhibit 68. Other Tissue/Muscle Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	243
3.13 Analysis by Origin	244
Exhibit 69. Biological Implants - Global Market Estimations & Predictions (2005 - 2020) by Origin for Allograft and Xenograft in US$ Million	244
Exhibit 70. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Origin for Allograft and Xenograft	245
3.13.1 Allograft	246
3.13.1.1 Global Allograft Implants Market	246
Exhibit 71. Allograft Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	246
Exhibit 72. Allograft Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	247
3.13.1.2 North American Allograft Implants Market	248
Exhibit 73. Allograft Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	249
Exhibit 74. Allograft Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	250
3.13.1.3 European Allograft Implants Market	251
Exhibit 75. Allograft Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	251
Exhibit 76. Allograft Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	252
3.13.1.4 Asia-Pacific Allograft Implants Market	253
Exhibit 77. Allograft Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	253
Exhibit 78. Allograft Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific	254
3.13.1.5 Rest of World Allograft Implants Market	255
Exhibit 79. Allograft Implants – Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	255
Exhibit 80. Xenograft Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	256
Exhibit 81. List of Allograft Banks	256
3.13.2 Xenograft	257
3.13.2.1 Global Xenograft Implants Market	257
Exhibit 82. Xenograft Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	257
Exhibit 83. Xenograft Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	258
3.13.2.2 North American Xenograft Implants Market	259
Exhibit 84. Xenograft Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	259
Exhibit 85. Xenograft Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	260
3.13.2.3 European Xenograft Implants Market	261
Exhibit 86. Xenograft Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	261
Exhibit 87. Xenograft Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	262
3.13.2.4 Asia-Pacific Xenograft Implants Market	263
Exhibit 88. Xenograft Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	263
Exhibit 89. Xenograft Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific	264
3.13.2.5 Rest of World Xenograft Implants Market	265
Exhibit 90. Xenograft Implants – Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	265
Exhibit 91. Xenograft Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	266
3.14 Analysis by Mode of Administration	267
Exhibit 92. Biological Implants - Global Market Estimations & Predictions (2005 - 2020) by Mode of Administration for Surgical and Injectable in US$ Million	267
Exhibit 93. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Mode of Administration for Surgical and Injectable	268
3.14.1 Surgical	269
3.14.1.1 Global Surgical Biological Implants Market	269
Exhibit 94. Surgical Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	269
Exhibit 95. Surgical Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	270
3.14.1.2 North American Surgical Biological Implants Market	271
Exhibit 96. Surgical Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	271
Exhibit 97. Surgical Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	272
3.14.1.3 European Surgical Biological Implants Market	273
Exhibit 98. Surgical Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	273
Exhibit 99. Surgical Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	274
3.14.1.4 Asia-Pacific Surgical Biological Implants Market	275
Exhibit 100. Surgical Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	275
Exhibit 101. Surgical Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific	276
3.14.1.5 Rest of World Surgical Biological Implants Market	277
Exhibit 102. Surgical Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	277
Exhibit 103. Surgical Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	278
3.14.2 Injectable	279
3.14.2.1 Global Injectable Biological Implants Market	279
Exhibit 104. Injectable Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million	279
Exhibit 105. Injectable Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World	280
3.14.2.2 North American Injectable Biological Implants Market	281
Exhibit 106. Injectable Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million	281
Exhibit 107. Injectable Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada	282
3.14.2.3 European Injectable Biological Implants Market	283
Exhibit 108. Injectable Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million	283
Exhibit 109. Injectable Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe	284
3.14.2.4 Asia-Pacific Injectable Biological Implants Market	285
Exhibit 110. Injectable Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million	285
Exhibit 111. Injectable Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Rest of Asia-Pacific	286
3.14.2.5 Rest of World Injectable Biological Implants Market	287
Exhibit 112. Injectable Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million	287
Exhibit 113. Injectable Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries	288
3.15 Biological Implants – Market Outlook	289
4. PRODUCT/TECHNOLOGY RESEARCH	290
4.1 Introduction	290
Medical Implants	290
Concerns Associated with Medical Implants	290
Microbial Contamination of the Implant	290
Inflammation due to implantation	291
Implant induced coagulation	291
Bioimplants	291
4.2 Segmentation of Biological Implants	292
Segmentation by Tissue/Muscle	292
Soft Tissue Biological Implants	292
Soft tissue implants are used for the following purposes:	292
Biological Implants in Cosmetic Surgery	292
Lip Augmentation Using Bioimplants:	292
Allograft Implants Used in Lip Augmentation:	292
Types and Characteristics of Various Allograft Implants	292
Alloderm	292
Apligraft	293
Cosmoderm I & 2	293
Cosmoplast	293
Cymetra or Micronized Alloderm	293
Cymetra should not be used in the following cases	294
Precautions	294
Fascian	294
Surgisis Soft Tissue Graft & Surgisis ES Soft Tissue Graft	294
Self Derived (Autologous) Implants & Injectables	295
Types and Characteristics of Autologous Implants	295
Autologen	295
Dermis Grafts	295
Dermis Fat Grafts	295
Fascia Grafts	295
Fat Grafting, Transfer or Transplanting	295
Drawbacks	295
Isolagen	296
Scar Tissue Grafting	296
Tendon Grafting	296
Application Biological Implants	296
Function and Use of Biological Implants	296
Application of Biological Implants in ENT surgery	297
Location of the Bioimplant: Middle Ear	297
Ossicle Replacement Draws Mixed Response	297
Tympanoplasty	297
Traumatic Perforation Using Fibrin-coated Collagen	297
Location of the Bioimplant: Paranasal Sinuses and Cranial Bones	298
Orbital Wall Reconstructions Using Allogenic Materials	298
Location of the Bioimplant: Bone and Cartilage of the Nose	298
Allogenic Materials to Develop Cartilage	298
Septal Abscess	298
Soft Tissue Implants	298
Location of the Bioimplant: Base of the Skull	299
Allogenic Materials to Treat Dural Defects	299
Allogenic Materials Required to Accomplish Duraplasty	299
Application of Fibrin Glues in ENT Surgeries	299
Location of the Bioimplant: Trachea/Larynx	300
Replacement of Trachea Using Solvent-preserved Allogenic Variety of Trachea	300
Various Disorders of Vocal Cord	300
Location of the Bioimplant: Skin	300
Process of Skin Replacement	300
Wrinkle Lift Treatment	300
Global Market Analysis for Cosmetic Surgery	301
Exhibit 114. Cosmetic Surgery – Global Market Estimations & Predictions (2005 - 2020) for Cosmetic Surgery in North America, Europe, Asia, and Rest of World in US$ Billion	301
Exhibit 115. Cosmetic Surgery – Global Market Shares (2010, 2015 & 2020) for Cosmetic Surgery in North America, Europe, Asia – Pacific and Rest of World	302
Orthopedic Biological Implants	302
Bone Graft Substitutes	302
Osteoinductive Agents - Substitute for Bone Allografts	303
Fibrin Matrix	303
Cardiovascular Biological Implants	304
Other (Dental, Ophthalmic, Urologic)	304
Other Tissue/Muscle Biological Implant Products	304
Dental Biological Implants	305
Ophthalmic Biological Implants	305
4.3 Segmentation by Origin of Biological Implants	305
Allograft and Xenograft Implants	305
Autografts and their Limitations	305
Utilization of the Allograft Bone Tissue	306
Limitations of the Process	306
Few Disadvantages of Using Allografts	307
Preventive Measures for Warding Infection	307
Bone Grafting	307
Advancements	307
Xenografts	308
Using Valved Porcine Xenografts in the Right Ventricle Outlet for Congenital Anomalies	308
Other Avenues of Research	309
L-Hydro Method	309
Allograft Biological Implants	309
Allograft Bone Tissue – Processing	309
Preparation for Biotransplantation	309
Allograft Bone Tissue	310
Base Tissue Segment	310
Processing of Allograft Bone Tissue	311
Processing of Grafton ® DBM – A Biological Implant Product of Osteotech	311
CXC TECHNOLOGY	312
Process of Tissue Processing Using Tutogen’s Tutoplast®	312
Process of Manufacture and Processing of Allografts	313
Quality Assurance Test	313
Stentless Porcine Xenograft (Mitral Valve Replacement)	313
Mitral Valve Replacement	313
4.4 Segmentation by Mode of Administration	314
Injectable Fillers for Soft Tissue Augmentation	314
Types of Augmentation Materials	314
Osteogenic Injectable Bone Substitutes	315
Hyaluronic Acid	315
Biological Synthesis	315
Biological Functions	316
HA and Cancer Metastasis	317
Appilcations	317
In Medicine	317
In Cosmetics	317
For Horses	318
Industrial Production of HA	318
Surgical Biological Implants	318
Organ Transplantation	318
3D-Bioprinting	319
4.5 Biological Implants – Research Briefs	320
Magnesium Surgical Implants to be Biodegradable and Influence the Bone Development	320
Autografts May be Useful for ACL Reconstructions	320
Developing Novel Nerve Repair Technology	321
Southampton Team of Scientists and Doctors Use 3D Printed Implant and Bone Stem Cell Graft for Successful Hip and Stem Cell Surgery	322
Young Athletes with Knee Pain Might Try Meniscus Transplant	322
Cell Recruitment by Amnion Chorion Grafts Promotes Neovascularization	323
Technological Developments Increase Long Term Survival of Transplanted Hearts in all Species	323
Rejection in Xenotransplantation	324
Interspecies Transplantation is Successful in the Initial Step in a Novel Process for Diabetes Treatment	325
Coatings Can Improve Functioning of Medical Implants	326
Engineered Biomaterial Could Improve Success of Medical Implants	327
Grafts from Bone Marrow Can Provide Relief to Patients Having Lower Back Pain	328
Nasal Lining to Breach Blood/Brain Barrier	329
Stem Cells Used to Fill Gaps in Bones	329
Processing autologous stem cells in the operating theatre	330
Investigators Expedite Success Rate of Tooth Implants	330
Investigators Apply Coating of Bioactive Film on Spinal Polymer Implants to Improve Bonding with Bone	331
Now Wooden Implants Substituting Damaged Bones	332
Post Stem Cell Transplantations, Survivors at Higher Risk of Developing Heart Disease	332
Gene Therapy to Cure Bone Defects	334
Liquorice Provides Clue to Cleaner Medical Implants	335
New Compound that could be used as a Substitute for Bone Glue Developed by Researchers	336
Human Tissue - Textile Developed by Cytograft Researchers	336
Xenotransplantation - Therapy for Type 1 Diabetes	337
Impact of Classical Music on Organ Transplant Rejection Revealed In Mice	338
Building Bone from Cartilage: Orthopedic Researchers Take the Road Less Travelled	338
Oocyte-Producing Stem Cells Identified from Human Ovaries	339
New Method of Cartilage Graft Developed for Bone Regeneration	339
IDIBELL Researchers Develops a Protocol for Transplanting Pig Cells to Regenerate Human Cartilage	340
Scientists Develop 'Living Bandage' for Speedy Healing Process	341
New Nanocomposite Materials to be used in Microturbines, Microreactors, and Bioimplants	341
Expanding the Pool of Liver Grafts and Transplants	342
A Better Disc for Back Repair	342
Russia Approves First Xenotransplantation based Therapeutics for Treating Diabetes	343
New Bioprosthetic Tissue Heart Valve for Severe Aortic Stenosis Shown to Save Lives	343
New Bone-Hard Biomaterial for Surgical Screws	344
A Brighter Future for Retinal Implants	344
Placenta – derived Stem Cells May Help Sufferers of Lung Diseases	345
First Ever System of Human Nerve Cell Tissue Engineered	345
Freeze –Dried Tendon Implants Loaded with Gene Therapy Prove Effective in Mice	346
Brain Implants to Restore Vision	347
Restoring Damaged Knees	347
Patients Who Receive Kidneys from Older Donors Do Well	348
V. CORPORATE DIRECTORY	349
VI. PATENTS INFORMATION	365

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