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Neurofibromatoses - Pipeline Review, H2 2016

Published: Dec, 2016 | Pages: 71 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Neurofibromatoses - Pipeline Review, H2 2016

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Neurofibromatoses - Pipeline Review, H2 2016, provides an overview of the Neurofibromatoses (Genetic Disorders) pipeline landscape.

Neurofibromatosis (commonly abbreviated NF; neurofibromatosis type 1 is also known as von Recklinghausen disease) is a genetically-inherited disorder in which the nerve tissue grows tumors (neurofibromas) that may be benign or may cause serious damage by compressing nerves and other tissues. The disorder affects all neural crest cells (Schwann cells, melanocytes and endoneurial fibroblasts). Cellular elements from these cell types proliferate excessively throughout the body, forming tumors; melanocytes also function abnormally in this disease, resulting in disordered skin pigmentation and cafe au lait spots. The tumors may cause bumps under the skin, colored spots, skeletal problems, pressure on spinal nerve roots, and other neurological problems. 

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Neurofibromatoses - Pipeline Review, H2 2016, provides comprehensive information on the therapeutics under development for Neurofibromatoses (Genetic Disorders), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Neurofibromatoses (Genetic Disorders) pipeline guide also reviews of key players involved in therapeutic development for Neurofibromatoses and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase II, Phase 0, Preclinical and Discovery stages are 3, 1, 5 and 2 respectively. Similarly, the Universities portfolio in Phase II, Preclinical and Discovery stages comprises 1, 1 and 1 molecules, respectively.

Neurofibromatoses (Genetic Disorders) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The pipeline guide provides a snapshot of the global therapeutic landscape of Neurofibromatoses (Genetic Disorders).
- The pipeline guide reviews pipeline therapeutics for Neurofibromatoses (Genetic Disorders) by companies and universities/research institutes based on information derived from company and industry-specific sources. 
- The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
- The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
- The pipeline guide reviews key companies involved in Neurofibromatoses (Genetic Disorders) therapeutics and enlists all their major and minor projects.
- The pipeline guide evaluates Neurofibromatoses (Genetic Disorders) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
- The pipeline guide encapsulates all the dormant and discontinued pipeline projects. 
- The pipeline guide reviews latest news related to pipeline therapeutics for Neurofibromatoses (Genetic Disorders)

Reasons To Buy

- Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
- Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
- Find and recognize significant and varied types of therapeutics under development for Neurofibromatoses (Genetic Disorders).
- Classify potential new clients or partners in the target demographic.
- Develop tactical initiatives by understanding the focus areas of leading companies.
- Plan mergers and acquisitions meritoriously by identifying key players and it's most promising pipeline therapeutics.
- Formulate corrective measures for pipeline projects by understanding Neurofibromatoses (Genetic Disorders) pipeline depth and focus of Indication therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.
 Table of Contents
Table of Contents 2 List of Tables 4 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Neurofibromatoses Overview 7 Therapeutics Development 8 Pipeline Products for Neurofibromatoses - Overview 8 Pipeline Products for Neurofibromatoses - Comparative Analysis 9 Neurofibromatoses - Therapeutics under Development by Companies 10 Neurofibromatoses - Therapeutics under Investigation by Universities/Institutes 11 Neurofibromatoses - Pipeline Products Glance 12 Clinical Stage Products 12 Early Stage Products 13 Neurofibromatoses - Products under Development by Companies 14 Neurofibromatoses - Products under Investigation by Universities/Institutes 15 Neurofibromatoses - Companies Involved in Therapeutics Development 16 Alexion Pharmaceuticals Inc 16 Arno Therapeutics Inc 17 AstraZeneca Plc 18 Betta Pharmaceuticals Co Ltd 19 Celldex Therapeutics Inc 20 Lixte Biotechnology Holdings Inc 21 Novartis AG 22 Plex Pharmaceuticals Inc 23 Neurofibromatoses - Therapeutics Assessment 24 Assessment by Monotherapy Products 24 Assessment by Target 25 Assessment by Mechanism of Action 27 Assessment by Route of Administration 29 Assessment by Molecule Type 31 Drug Profiles 33 AR-42 - Drug Profile 33 Product Description 33 Mechanism Of Action 33 R&D Progress 33 asfotase alfa - Drug Profile 35 Product Description 35 Mechanism Of Action 35 R&D Progress 35 CDX-0158 - Drug Profile 39 Product Description 39 Mechanism Of Action 39 R&D Progress 39 everolimus - Drug Profile 41 Product Description 41 Mechanism Of Action 41 R&D Progress 41 FRAX-597 - Drug Profile 52 Product Description 52 Mechanism Of Action 52 R&D Progress 52 icotinib hydrochloride - Drug Profile 53 Product Description 53 Mechanism Of Action 53 R&D Progress 53 LB-201 - Drug Profile 55 Product Description 55 Mechanism Of Action 55 R&D Progress 55 LB-205 - Drug Profile 56 Product Description 56 Mechanism Of Action 56 R&D Progress 56 OS-342 - Drug Profile 57 Product Description 57 Mechanism Of Action 57 R&D Progress 57 selumetinib sulfate - Drug Profile 58 Product Description 58 Mechanism Of Action 58 R&D Progress 58 Small Molecule to Inhibit Hsp90-Alpha and TRAP1 for Neurofibromatosis Type 2 - Drug Profile 63 Product Description 63 Mechanism Of Action 63 R&D Progress 63 Small Molecules for Neurofibromatoses Type I - Drug Profile 64 Product Description 64 Mechanism Of Action 64 R&D Progress 64 Vaccine to Target VEGFR1 and VEGFR2 for Oncology - Drug Profile 65 Product Description 65 Mechanism Of Action 65 R&D Progress 65 VAL-0524 - Drug Profile 66 Product Description 66 Mechanism Of Action 66 R&D Progress 66 Neurofibromatoses - Dormant Projects 67 Neurofibromatoses - Discontinued Products 68 Neurofibromatoses - Product Development Milestones 69 Featured News & Press Releases 69 May 11, 2012: Arno Therapeutics Receives European Orphan Drug Designation For AR-42 69 Appendix 70 Methodology 70 Coverage 70 Secondary Research 70 Primary Research 70 Expert Panel Validation 70 Contact Us 70 Disclaimer 71
List of Tables
Number of Products under Development for Neurofibromatoses, H2 2016 8 Number of Products under Development for Neurofibromatoses - Comparative Analysis, H2 2016 9 Number of Products under Development by Companies, H2 2016 10 Number of Products under Investigation by Universities/Institutes, H2 2016 11 Comparative Analysis by Clinical Stage Development, H2 2016 12 Comparative Analysis by Early Stage Development, H2 2016 13 Products under Development by Companies, H2 2016 14 Products under Investigation by Universities/Institutes, H2 2016 15 Neurofibromatoses - Pipeline by Alexion Pharmaceuticals Inc, H2 2016 16 Neurofibromatoses - Pipeline by Arno Therapeutics Inc, H2 2016 17 Neurofibromatoses - Pipeline by AstraZeneca Plc, H2 2016 18 Neurofibromatoses - Pipeline by Betta Pharmaceuticals Co Ltd, H2 2016 19 Neurofibromatoses - Pipeline by Celldex Therapeutics Inc, H2 2016 20 Neurofibromatoses - Pipeline by Lixte Biotechnology Holdings Inc, H2 2016 21 Neurofibromatoses - Pipeline by Novartis AG, H2 2016 22 Neurofibromatoses - Pipeline by Plex Pharmaceuticals Inc, H2 2016 23 Assessment by Monotherapy Products, H2 2016 24 Number of Products by Stage and Target, H2 2016 26 Number of Products by Stage and Mechanism of Action, H2 2016 28 Number of Products by Stage and Route of Administration, H2 2016 30 Number of Products by Stage and Molecule Type, H2 2016 32 Neurofibromatoses - Dormant Projects, H2 2016 67 Neurofibromatoses - Discontinued Products, H2 2016 68



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