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Meningitis - Pipeline Review, H2 2016

Published: Dec, 2016 | Pages: 67 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Meningitis - Pipeline Review, H2 2016

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Meningitis - Pipeline Review, H2 2016, provides an overview of the Meningitis (Infectious Disease) pipeline landscape.

Meningitis is the inflammation caused by viruses and bacteria on the protective membranes covering the brain and spinal cord. The cause of inflammation can be infection by viruses, bacteria, or other microorganisms, and less commonly by certain drugs. As the inflammation is in proximity to the brain and spinal cord, meningitis can be life threatening. Viral meningitis is not life-threatening and the people affected with this can be cured and recover quickly, but bacterial meningitis is serious and life-threatening. There are three major bacteria which lead to bacterial meningitis. Neisseria meningitides are one of these, and causes meningococcal meningitis. Researchers have identified 13 major serogroups of N. meningitides, out of which the majority of cases are from one of five serogroups: A, B, C, Y and W-135. Drugs and vaccines are available to treat the serogroups AC, C, ACWY, and A. There are also vaccines available to prevent meningitis caused by serogroups A, C, Y, W-135. There are no vaccines or drugs available for the prevention and treatment of meningococcal meningitis caused by serogroup B. This represents a major unmet need in the market. Pneumococcal meningitis is another major bacterial cause of meningitis, caused by the bacteria streptococcus pneumonia, while haemophilius influenza is the third, and causes meningitis in infants. Approximatiely 44-46% cases of bacterial meningitis have all of the following three symptoms - severe headache, nuchal ridgidity ((inability to flex the neck forward passively due to increased neck muscle tone and stiffness) and altered mental status. Out of this triad of symptoms severe headache is the most common and occurs in 90% of the cases. If nove of the above mentioned symptoms are present, then occurrence of bacterial meningitis is least likely. Other clinical feature include photophobia (fear of bright light), phonophobia (fear of loud noises). In small children above symptoms are difficult to spot. Vague symptoms like irritability and unwell appearance are more common in them. In infants up to 6 months bulging of the fontanelle (soft spot on baby's head) may be visible. Other less severe illnesses like extreme cold, abnormality in skin color and leg pain may also be distinguishing features for meningitis. 

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Meningitis - Pipeline Review, H2 2016, provides comprehensive information on the therapeutics under development for Meningitis (Infectious Disease), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Meningitis (Infectious Disease) pipeline guide also reviews of key players involved in therapeutic development for Meningitis and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 1, 1, 4, 3 and 6 respectively. Similarly, the Universities portfolio in Preclinical stages comprises 3 molecules, respectively.

Meningitis (Infectious Disease) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The pipeline guide provides a snapshot of the global therapeutic landscape of Meningitis (Infectious Disease).
- The pipeline guide reviews pipeline therapeutics for Meningitis (Infectious Disease) by companies and universities/research institutes based on information derived from company and industry-specific sources. 
- The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
- The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
- The pipeline guide reviews key companies involved in Meningitis (Infectious Disease) therapeutics and enlists all their major and minor projects.
- The pipeline guide evaluates Meningitis (Infectious Disease) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
- The pipeline guide encapsulates all the dormant and discontinued pipeline projects. 
- The pipeline guide reviews latest news related to pipeline therapeutics for Meningitis (Infectious Disease)

Reasons To Buy

- Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
- Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
- Find and recognize significant and varied types of therapeutics under development for Meningitis (Infectious Disease).
- Classify potential new clients or partners in the target demographic.
- Develop tactical initiatives by understanding the focus areas of leading companies.
- Plan mergers and acquisitions meritoriously by identifying key players and it's most promising pipeline therapeutics.
- Formulate corrective measures for pipeline projects by understanding Meningitis (Infectious Disease) pipeline depth and focus of Indication therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.
 Table of Contents
Table of Contents 2 List of Tables 5 List of Figures 6 Introduction 7 Global Markets Direct Report Coverage 7 Meningitis Overview 8 Therapeutics Development 9 Pipeline Products for Meningitis - Overview 9 Pipeline Products for Meningitis - Comparative Analysis 10 Meningitis - Therapeutics under Development by Companies 11 Meningitis - Therapeutics under Investigation by Universities/Institutes 12 Meningitis - Pipeline Products Glance 13 Late Stage Products 13 Clinical Stage Products 14 Early Stage Products 15 Meningitis - Products under Development by Companies 16 Meningitis - Products under Investigation by Universities/Institutes 17 Meningitis - Companies Involved in Therapeutics Development 18 Adenium Biotech ApS 18 Amplyx Pharmaceuticals Inc 19 Chiesi Farmaceutici SpA 20 Chongqing Zhifei Biological Products Co Ltd 21 ContraFect Corp 22 LG Life Science LTD 23 Matinas BioPharma Holdings Inc 24 Sanofi Pasteur SA 25 Viamet Pharmaceuticals Inc 26 Meningitis - Therapeutics Assessment 27 Assessment by Monotherapy Products 27 Assessment by Combination Products 28 Assessment by Target 29 Assessment by Mechanism of Action 31 Assessment by Route of Administration 33 Assessment by Molecule Type 35 Drug Profiles 37 (Haemophilus influenzae [serotype B] + meningococcal [serotypes A, C]) vaccine - Drug Profile 37 Product Description 37 Mechanism Of Action 37 R&D Progress 37 amphotericin B - Drug Profile 38 Product Description 38 Mechanism Of Action 38 R&D Progress 38 AP-114 - Drug Profile 41 Product Description 41 Mechanism Of Action 41 R&D Progress 41 CF-301 - Drug Profile 42 Product Description 42 Mechanism Of Action 42 R&D Progress 42 CF-302 - Drug Profile 45 Product Description 45 Mechanism Of Action 45 R&D Progress 45 CF-303 - Drug Profile 46 Product Description 46 Mechanism Of Action 46 R&D Progress 46 CF-305 - Drug Profile 47 Product Description 47 Mechanism Of Action 47 R&D Progress 47 CF-309 - Drug Profile 48 Product Description 48 Mechanism Of Action 48 R&D Progress 48 Eupenta - Drug Profile 49 Product Description 49 Mechanism Of Action 49 R&D Progress 49 LBVD - Drug Profile 50 Product Description 50 Mechanism Of Action 50 R&D Progress 50 meningitis vaccine - Drug Profile 51 Product Description 51 Mechanism Of Action 51 R&D Progress 51 meningococcal [serotypes A, C, W135, X, Y] vaccine - Drug Profile 52 Product Description 52 Mechanism Of Action 52 R&D Progress 52 meningococcal [serotypes A, C] vaccine - Drug Profile 53 Product Description 53 Mechanism Of Action 53 R&D Progress 53 meropenem - Drug Profile 54 Product Description 54 Mechanism Of Action 54 R&D Progress 54 pneumococcal [serotype 4, 6A] vaccine - Drug Profile 55 Product Description 55 Mechanism Of Action 55 R&D Progress 55 Small Molecules to Inhibit Pkh2-02 for Cryptococcal Meningitis - Drug Profile 56 Product Description 56 Mechanism Of Action 56 R&D Progress 56 Streptococcus pneumonia vaccine - Drug Profile 57 Product Description 57 Mechanism Of Action 57 R&D Progress 57 tuberculous meningitis vaccine - Drug Profile 58 Product Description 58 Mechanism Of Action 58 R&D Progress 58 VT-1129 - Drug Profile 59 Product Description 59 Mechanism Of Action 59 R&D Progress 59 Meningitis - Dormant Projects 61 Meningitis - Discontinued Products 62 Meningitis - Product Development Milestones 63 Featured News & Press Releases 63 Jun 16, 2016: Clinical Trial of Phase III of Group A and Group C Meningococcal Conjugate vaccine Phase III Clinical Trial Initiated 63 Jun 01, 2016: Viamet Receives Fast Track Designation from the FDA for VT-1129 for the Treatment of Cryptococcal Meningitis 63 Sep 16, 2015: FDA Grants QIDP Designation to VT-1129 for Treatment of Cryptococcal Meningitis 63 Jun 29, 2015: Olymvax obtains Chinese approval for clinical trials of Meningococcal conjugate vaccine 64 Apr 24, 2015: Viamet to Provide Update on VT-1129, Novel Antifungal Program at ECCMID 2015 64 Apr 01, 2015: LG Life Sciences Succeeds in Phase 3 International Clinical Trials for 5-in-1 Vaccine Eupenta 64 Sep 11, 2014: Viamet Receives Orphan Drug Designation for VT-1129 65 Appendix 66 Methodology 66 Coverage 66 Secondary Research 66 Primary Research 66 Expert Panel Validation 66 Contact Us 66 Disclaimer 67
List of Tables
Number of Products under Development for Meningitis, H2 2016 9 Number of Products under Development for Meningitis - Comparative Analysis, H2 2016 10 Number of Products under Development by Companies, H2 2016 11 Number of Products under Investigation by Universities/Institutes, H2 2016 12 Comparative Analysis by Late Stage Development, H2 2016 13 Comparative Analysis by Clinical Stage Development, H2 2016 14 Comparative Analysis by Early Stage Development, H2 2016 15 Products under Development by Companies, H2 2016 16 Products under Investigation by Universities/Institutes, H2 2016 17 Meningitis - Pipeline by Adenium Biotech ApS, H2 2016 18 Meningitis - Pipeline by Amplyx Pharmaceuticals Inc, H2 2016 19 Meningitis - Pipeline by Chiesi Farmaceutici SpA, H2 2016 20 Meningitis - Pipeline by Chongqing Zhifei Biological Products Co Ltd, H2 2016 21 Meningitis - Pipeline by ContraFect Corp, H2 2016 22 Meningitis - Pipeline by LG Life Science LTD, H2 2016 23 Meningitis - Pipeline by Matinas BioPharma Holdings Inc, H2 2016 24 Meningitis - Pipeline by Sanofi Pasteur SA, H2 2016 25 Meningitis - Pipeline by Viamet Pharmaceuticals Inc, H2 2016 26 Assessment by Monotherapy Products, H2 2016 27 Assessment by Combination Products, H2 2016 28 Number of Products by Stage and Target, H2 2016 30 Number of Products by Stage and Mechanism of Action, H2 2016 32 Number of Products by Stage and Route of Administration, H2 2016 34 Number of Products by Stage and Molecule Type, H2 2016 36 Meningitis - Dormant Projects, H2 2016 61 Meningitis - Discontinued Products, H2 2016 62



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