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Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline Review, H2 2016

Published: Nov, 2016 | Pages: 53 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline Review, H2 2016

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline Review, H2 2016, provides an overview of the Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders) pipeline landscape.

Homozygous familial hypercholesterolemia is a genetic disorder which is caused due to mutation from both parents. HoFH causes LDL cholesterol level to be very high. Symptoms include xanthelasmas, chest pain and sores on the toes that do not heal. Treatment includes diet changes and statin drugs. 

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline Review, H2 2016, provides comprehensive information on the therapeutics under development for Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders) pipeline guide also reviews of key players involved in therapeutic development for Homozygous Familial Hypercholesterolemia (HoFH) and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase II, Phase I, Preclinical and Discovery stages are 5, 1, 3 and 1 respectively.Homozygous Familial Hypercholesterolemia (HoFH).

Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The pipeline guide provides a snapshot of the global therapeutic landscape of Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders).
- The pipeline guide reviews pipeline therapeutics for Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders) by companies and universities/research institutes based on information derived from company and industry-specific sources. 
- The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
- The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
- The pipeline guide reviews key companies involved in Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders) therapeutics and enlists all their major and minor projects.
- The pipeline guide evaluates Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
- The pipeline guide encapsulates all the dormant and discontinued pipeline projects. 
- The pipeline guide reviews latest news related to pipeline therapeutics for Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders)

Reasons To Buy

- Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
- Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
- Find and recognize significant and varied types of therapeutics under development for Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders).
- Classify potential new clients or partners in the target demographic.
- Develop tactical initiatives by understanding the focus areas of leading companies.
- Plan mergers and acquisitions meritoriously by identifying key players and it's most promising pipeline therapeutics.
- Formulate corrective measures for pipeline projects by understanding Homozygous Familial Hypercholesterolemia (HoFH) (Metabolic Disorders) pipeline depth and focus of Indication therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.
 Table of Contents
Table of Contents 2 List of Tables 4 List of Figures 4 Introduction 5 Global Markets Direct Report Coverage 5 Homozygous Familial Hypercholesterolemia (HoFH) Overview 6 Therapeutics Development 7 Pipeline Products for Homozygous Familial Hypercholesterolemia (HoFH) - Overview 7 Homozygous Familial Hypercholesterolemia (HoFH) - Therapeutics under Development by Companies 8 Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline Products Glance 10 Clinical Stage Products 10 Early Stage Products 11 Homozygous Familial Hypercholesterolemia (HoFH) - Products under Development by Companies 12 Homozygous Familial Hypercholesterolemia (HoFH) - Companies Involved in Therapeutics Development 13 ARMO Biosciences Inc 13 CymaBay Therapeutics Inc 14 Gemphire Therapeutics Inc 15 LipimetiX Development Inc 16 Regeneron Pharmaceuticals Inc 17 RegenxBio Inc 18 Homozygous Familial Hypercholesterolemia (HoFH) - Therapeutics Assessment 19 Assessment by Monotherapy Products 19 Assessment by Target 20 Assessment by Mechanism of Action 22 Assessment by Route of Administration 24 Assessment by Molecule Type 26 Drug Profiles 28 AEM-28 - Drug Profile 28 Product Description 28 Mechanism Of Action 28 R&D Progress 28 AEM-2802 - Drug Profile 30 Product Description 30 Mechanism Of Action 30 R&D Progress 30 AEM-2814 - Drug Profile 31 Product Description 31 Mechanism Of Action 31 R&D Progress 31 AM-0010 - Drug Profile 32 Product Description 32 Mechanism Of Action 32 R&D Progress 32 evinacumab - Drug Profile 35 Product Description 35 Mechanism Of Action 35 R&D Progress 35 gemcabene calcium - Drug Profile 37 Product Description 37 Mechanism Of Action 37 R&D Progress 37 MBX-8025 - Drug Profile 39 Product Description 39 Mechanism Of Action 39 R&D Progress 39 MGL-3196 - Drug Profile 42 Product Description 42 Mechanism Of Action 42 R&D Progress 42 MGL-3745 - Drug Profile 44 Product Description 44 Mechanism Of Action 44 R&D Progress 44 RGX-501 - Drug Profile 45 Product Description 45 Mechanism Of Action 45 R&D Progress 45 Homozygous Familial Hypercholesterolemia (HoFH) - Dormant Projects 47 Homozygous Familial Hypercholesterolemia (HoFH) - Product Development Milestones 48 Featured News & Press Releases 48 Sep 26, 2016: Gemphire Therapeutics Enrolls First Patient in the COBALT-1 Trial Investigating Gemcabene in Homozygous Familial Hypercholesterolemia 48 May 31, 2016: Regeneron Presents Positive Interim Data from Phase 2 Proof-of-Concept Study of Evinacumab in Patients with Homozygous Familial Hypercholesterolemia 48 Mar 17, 2016: CymaBay Therapeutics Announces Positive Results from its Pilot Phase 2 Clinical Study of MBX-8025 in Patients with Homozygous Familial Hypercholesterolemia 49 Apr 23, 2015: CymaBay Therapeutics Announces the Initiation of a Phase 2 Study of MBX-8025 in Patients With Homozygous Familial Hypercholesterolemia 50 Mar 25, 2015: CymaBay Therapeutics Announces U.S. Orphan Drug Designation for MBX-8025 in Homozygous Familial Hypercholesterolemia 51 Appendix 52 Methodology 52 Coverage 52 Secondary Research 52 Primary Research 52 Expert Panel Validation 52 Contact Us 52 Disclaimer 53
List of Tables
Number of Products under Development for Homozygous Familial Hypercholesterolemia (HoFH), H2 2016 7 Number of Products under Development by Companies, H2 2016 9 Comparative Analysis by Clinical Stage Development, H2 2016 10 Comparative Analysis by Early Stage Development, H2 2016 11 Products under Development by Companies, H2 2016 12 Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline by ARMO Biosciences Inc, H2 2016 13 Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline by CymaBay Therapeutics Inc, H2 2016 14 Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline by Gemphire Therapeutics Inc, H2 2016 15 Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline by LipimetiX Development Inc, H2 2016 16 Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline by Regeneron Pharmaceuticals Inc, H2 2016 17 Homozygous Familial Hypercholesterolemia (HoFH) - Pipeline by RegenxBio Inc, H2 2016 18 Assessment by Monotherapy Products, H2 2016 19 Number of Products by Stage and Target, H2 2016 21 Number of Products by Stage and Mechanism of Action, H2 2016 23 Number of Products by Stage and Route of Administration, H2 2016 25 Number of Products by Stage and Molecule Type, H2 2016 27 Homozygous Familial Hypercholesterolemia (HoFH) - Dormant Projects, H2 2016 47



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