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Cerebral Palsy - Pipeline Review, H1 2015

Published: Jan, 2015 | Pages: 53 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Cerebral palsy, in short, is also referred to as CP. It is a set of permanent disorders affecting human movements. CP may appear during early childhood. Symptoms & indications of this illness range from one person to another. Majority of the times, the signs comprise tight muscles, poor skills, tremors, and weak muscles. Cerebral palsy patients may also have issues regarding vision, sensations, hearing, swallowing food, and speaking.

Quite frequently, babies with this condition are unable to crawl, turn over, sit, or walk like other children their age. Seizures and reasoning/thinking problems also arise in around one-third CP patients. Whilst the indications are evident in the initial years of one’s life, primary issues do not deteriorate with time. Rising CP incidences around the globe are projected to propel the cerebral palsy market in the near future.

The common cause of CP is damage to brain parts that control body balance, movements, and postures. Abnormal brain growth may also lead to cerebral palsy. Quite frequently, issues occur before, immediately after, or during birth. Some other times, CP causes are unknown. However, according to researchers, CP may also result from weak oxygen supply to the brain during, before, or instantly after birth. 

Cerebral palsy may also be a consequence of birth injuries & infections. It can be partially avoided by mothers being vaccinated and children being prevented from head injuries. CP remains incurable till date. However, medicines, supportive therapeutics, and surgeries could assist several patients. These consist of occupational therapy, speech therapy, and physical therapy. Medicines like baclofen, diazepam, & botulinum toxin can assist in loosening stiff muscles. 

Surgeries may involve slicing hyperactive nerves and enlarging the muscles. Other innovative technologies and external braces are useful in some other cases. Few children may be able to lead normal lives post their treatments. Quite often, alternative medications are used to treat this condition. However, there is no proof to back their adoption. Cerebral palsy is the most widely prevalent movement disorder in children. 

Increasing incidences of brain damages, anomalies, abnormalities, & defects during/after/before birth are also anticipated to drive the cerebral palsy market. CP is of three kinds. These include athetoid, spastic, and ataxic.  

Scope

- The report provides a snapshot of the global therapeutic landscape of Cerebral Palsy
- The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities 
- The report reviews key players involved in the therapeutics development for Cerebral Palsy and enlists all their major and minor projects
- The report summarizes all the dormant and discontinued pipeline projects 
- A review of the Cerebral Palsy products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- A detailed assessment of monotherapy and combination therapy pipeline projects
- Coverage of the Cerebral Palsy pipeline on the basis of target, MoA, route of administration and molecule type
- Latest news and deals relating related to pipeline products

Reasons to buy

- Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Develop strategic initiatives by understanding the focus areas of leading companies
- Identify and understand important and diverse types of therapeutics under development for Cerebral Palsy
- Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline
- Devise corrective measures for pipeline projects by understanding Cerebral Palsy pipeline depth and focus of Indication therapeutics
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
 Table of Contents

Table of Contents 
List of Tables 4
List of Figures 4

Introduction 5
Global Markets Direct Report Coverage 5
Cerebral Palsy Overview 6
Therapeutics Development 7
Pipeline Products for Cerebral Palsy - Overview 7
Pipeline Products for Cerebral Palsy - Comparative Analysis 8
Cerebral Palsy - Therapeutics under Development by Companies 9
Cerebral Palsy - Pipeline Products Glance 10
Late Stage Products 10
Clinical Stage Products 11
Early Stage Products 12
Cerebral Palsy - Products under Development by Companies 13
Cerebral Palsy - Companies Involved in Therapeutics Development 14
Acorda Therapeutics, Inc. 14
Allergan, Inc. 15
Cell Cure Neurosciences, Ltd. 16
Cellular Biomedicine Group, Inc. 17
CHA Bio & Diostech Co., Ltd. 18
K-Stemcell Co., Ltd. 19
Neuralstem, Inc. 20
Cerebral Palsy - Therapeutics Assessment 21
Assessment by Monotherapy Products 21
Assessment by Target 22
Assessment by Mechanism of Action 24
Assessment by Route of Administration 26
Assessment by Molecule Type 28
Drug Profiles 30
Astrostem - Drug Profile 30
Product Description 30
Mechanism of Action 30
R&D Progress 30
dalfampridine ER - Drug Profile 31
Product Description 31
Mechanism of Action 31
R&D Progress 31
NeurArrest - Drug Profile 33
Product Description 33
Mechanism of Action 33
R&D Progress 33
NSI-566 - Drug Profile 34
Product Description 34
Mechanism of Action 34
R&D Progress 34
onabotulinumtoxin A - Drug Profile 36
Product Description 36
Mechanism of Action 36
R&D Progress 36
Stem Cell Therapy for Cerebral Palsy - Drug Profile 38
Product Description 38
Mechanism of Action 38
R&D Progress 38
Stem Cell Therapy for Cerebral Palsy and Systemic Lupus Erythematosus - Drug Profile 39
Product Description 39
Mechanism of Action 39
R&D Progress 39
Cerebral Palsy - Recent Pipeline Updates 40
Cerebral Palsy - Product Development Milestones 51
Featured News & Press Releases 51
Feb 08, 2013: RNL BIO Files Investigational New Drug Application With KFDA For Phase II/III Clinical Trial Using Astrostem To Treat Cerebral Palsy 51

Appendix 52
Methodology 52
Coverage 52
Secondary Research 52
Primary Research 52
Expert Panel Validation 52
Contact Us 52
Disclaimer 53
List of Tables
Number of Products under Development for Cerebral Palsy, H1 2015 7
Number of Products under Development for Cerebral Palsy - Comparative Analysis, H1 2015 8
Number of Products under Development by Companies, H1 2015 9
Comparative Analysis by Late Stage Development, H1 2015 10
Comparative Analysis by Clinical Stage Development, H1 2015 11
Comparative Analysis by Early Stage Development, H1 2015 12
Products under Development by Companies, H1 2015 13
Cerebral Palsy - Pipeline by Acorda Therapeutics, Inc., H1 2015 14
Cerebral Palsy - Pipeline by Allergan, Inc., H1 2015 15
Cerebral Palsy - Pipeline by Cell Cure Neurosciences, Ltd., H1 2015 16
Cerebral Palsy - Pipeline by Cellular Biomedicine Group, Inc., H1 2015 17
Cerebral Palsy - Pipeline by CHA Bio & Diostech Co., Ltd., H1 2015 18
Cerebral Palsy - Pipeline by K-Stemcell Co., Ltd., H1 2015 19
Cerebral Palsy - Pipeline by Neuralstem, Inc., H1 2015 20
Assessment by Monotherapy Products, H1 2015 21
Number of Products by Stage and Target, H1 2015 23
Number of Products by Stage and Mechanism of Action, H1 2015 25
Number of Products by Stage and Route of Administration, H1 2015 27
Number of Products by Stage and Molecule Type, H1 2015 29
Cerebral Palsy Therapeutics - Recent Pipeline Updates, H1 2015 40 



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