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Published: Apr, 2015 | Pages:
576 | Publisher: RESEARCH IMPACT TECHNOLOGIES
Industry: Biotechnology | Report Format: Electronic (PDF)
This report on Biological Implants analyzes the global market for biological implant procedures. The total biological implants market is analyzed by tissue/muscle; origin, and mode of administration at global level and for each of the geographic regions - North America, Europe, Asia-Pacific and Rest of World. The biological implants market is segmented by Tissue/Muscle into Soft Tissue, Orthopedic, Cardiovascular and Other (includes Dental, Ophthalmic, and Urologic); by Origin into Allograft, and Xenograft; and by Mode of Administration into Injectable and Surgical. Business profiles of 25 major companies are discussed in the report. The report serves as a guide to global biological implants industry covering more 140 companies that are engaged in biological implants' processing, R&D, storage, banking, discovery, testing and supply of products and services. Major Contract Research Organizations and Universities serving the industry are also covered in the Corporate Directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, mergers and acquisitions, ethical issues, regulatory affairs, and other areas of concern is also covered in the report. Compilation of Worldwide Patents and Research related to biological implants is also provided. Estimations and Predictions are graphically illustrated by geographic regions by 117 exclusive exhibits.
Table of Content 1. SCOPE AND METHODOLOGY 1 2. REPORT SYNOPSIS 3 2.1 Introduction 3 Biological Implants – A Revolutionary Human Repair Technique 3 Medical Implants 3 An Overview of Medical Implants 3 History of Implants 4 The Need for a Better Implant 4 Naturally Derived Implants 4 Orbital Implants and Artificial Eyes 5 Artificial Skin 6 Hip Replacement 7 Tissues 7 Animal Tissues 8 Plant Tissues 9 Definitions 9 Implant 9 Transplant 9 Explant 9 Types of Implants 9 Artificial Implants 9 Prothesis 10 Bio-implant 10 Disadvantages of Artificial implants 10 Biological Implants 10 Tissue Engineering 10 2.2 Segmentation of Biological Implants 11 Exhibit 1. Segmentation of Global Biological Implants Market by Tissue/Muscle, by Origin and by Mode of Administration 11 2.2 Biological Implants - Global Market Analysis 12 Exhibit 2. Biological Implants – Global Market Estimations & Predictions (2005 – 2020) in US$ Million 12 Exhibit 3. List of Major Global Biological Implant Companies 13 3. MARKET DYNAMICS 14 3.1Global Market Overview 14 3.2 Global Medical Implants Market 14 Exhibit 4. Medical Implants – Global Market Estimations & Predictions (2005 - 2020) in US$ Billion 15 3.2.1 Spinal Implants 16 Exhibit 5. Spinal Implants – Global Market Estimations & Predictions (2005 - 2020) for Implants in North America, Europe, Asia, Canada and Rest of World in US$ Million 16 Exhibit 6. Spinal Implants – Global Market Shares (2010, 2015 & 2020) for Implants in North America, Europe, Asia-Pacific, Canada and Rest of World 17 3.2.2 Orthopedic Implants 18 Exhibit 7. Orthopedic Implants – Global Market Estimations & Predictions (2005 - 2020) for North America, Europe, Asia-Pacific, and Rest of World in US$ Million 18 Exhibit 8. Orthopedic Implants – Global Market Shares (2010, 2015 & 2020) for North America, Europe, Asia-Pacific, and Rest of World 19 3.2.3 Cardiovascular Implants 20 Exhibit 9. Cardiovascular Implants – Global Market Estimations & Predictions (2005 - 2020) for Cardiovascular Implants in North America, Europe, Asia, and Rest of World in US$ Million 20 Exhibit 10. Cardiovascular Implants – Global Market Shares (2010, 2015 & 2020) for Cardiovascular Implants in North America, Europe, Asia–Pacific, and Rest of World 21 3.2.4 Dental Implants 22 Exhibit 11. Dental Implants – Global Market Estimations & Predictions (2005 - 2020) for Dental Implants in North America, Europe, Asia, and Rest of World in US$ Million 22 Exhibit 12. Dental Implants – Global Market Shares (2010, 2015 & 2020) for Dental Implants in North America, Europe, Asia – Pacific, and Rest of World 23 Biological Implants 24 3.3 Global Biological Implants Market 24 Exhibit 13. Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific, and Rest of World in US$ Million 24 Exhibit 14. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 25 3.4 North American Biological Implants Market 26 Exhibit 15. Biological Implants –North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 26 Exhibit 16. Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 27 3.4 (I) United States Biological Implants Market 27 3.4 (II) Canadian Biological Implants Market 27 Exhibit 17. List of Major Biological Implants Companies in North America 27 3.5 European Biological Implants Market 29 Exhibit 18. Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 29 Exhibit 19. Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 30 3.5 (I) German Biological Implants Market 30 3.5 (II) United Kingdom Biological Implants Market 30 3.5 (III) French Biological Implants Market 30 3.5 (IV) Swiss Biological Implants Market 30 3.5 (V) Russian Biological Implants Market 31 Exhibit 20. List of Major Biological Implants Companies in Europe 31 3.6 Asia-Pacific Biological Implants Market 32 Exhibit 21. Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 32 Exhibit 22. Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific 33 3.6 (I) Australian Biological Implants Market 33 3.6 (II) Japanese Biological Implants Market 33 3.6 (III) Chinese Biological Implants Market 33 3.6 (IV) Indian Biological Implants Market 33 3.6 (V) South Korean Biological Implants Market 34 Exhibit 23. List of Major Biological Implants Companies in Asia-Pacific 34 3.7 Rest of World Biological Implants Market 35 Exhibit 24. Biological Implants – Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 35 Exhibit 25. Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 36 3.7 (I) Israeli Biological Implants Market 36 3.7 (II) Brazilian Biological Implants Market 36 3.7 (III) South African Biological Implants Market 36 3.8 Market Trends 37 3.9 Product Trends 38 Research and Development 38 Neovascularisation Promoting Membrane for Biological Implants 38 Biological Implants of Semipermeable Amphiphilic Membranes 38 Artificial Tissue Systems 39 Stem Cells in Biological Implants 39 Overview 39 Various Animal Models Used and Methods Followed 39 The Outcome 39 Analysis 40 The Journey of Embryonic Stem Cells from Fundamental Biology to Medicine Field 40 Application of Umbilical Cord Lining Cells as Therapeutic Bioimplants for Metabolic Disorders 40 Drug Delivery and Smart Biological Implants 40 Tissue Engineered Biological Implants 41 Biological Implants for Treatment of Vocal Fold Disorders 44 Systemic Inhibition of Tumor Growth using Biological Implants 45 Process of Secretion and Expression of TSP-2 Using Polymer-Cell Grafts in Vivo 45 Inhibition of Tumor Growth in Mice Containing TSP-2-secreting Bioimplants 46 Inhibition of Tumor Angiogenesis in Mice Containing TSP-2-secreted Bioimplants 46 Surgery for Valvular Heart Disease 47 RVOT Reconstruction 50 Bovine Valved Venous Xenografts for RVOT Reconstruction 50 Alloplastic Implants for the Treatment of Stress Urinary Incontinence 51 Repair of Cartilage Lesions 51 Repair of Cartilage Lesions Using Biological Implants - A Comparative Histological and Biomechanical Study in Goats 51 Cryopreservation of Human Ovarian Tissues 52 CXC Technology: ADAPT (Advanced Tissue Process) 52 Celxcel – Patches 52 Clinical Trials 53 Man Gets Teeth from Shoulder 53 Implantation of Esterified Hyaluronic Acid in Microdissected Reinke's Space after Vocal Fold Microsurgery 54 Healing of Brain and Bones 54 Saving Brain and Spines 55 The Perfect Knee 55 Get the Smile Back on Your Face 56 Mending Broken Hearts 56 Biological Implants in Sports Medicine 57 Allografts in Sports 57 Ligament Reconstruction 57 Meniscal Allograft 57 Osteochondral Allograft 57 Transplantation Genetics 58 Acceptance of Biological Implants 59 Biphasic Implants 60 Preparation of a Biphasic Scaffold 60 Devising Biological Implants for Healing of Joint Disorders 60 Biomaterials 61 The Construction of New Body Parts 61 Orthopedic Biomaterials 61 Heart Valve Biomaterials 62 Risk of Infection, Off – Label Use and Safety 63 Exhibit 26. Different Processes Used for Preservation of Allografts and Xenografts 64 Ethical Issues Concerning Biological Implants 64 Moral Issue and Balancing concept 64 Animal Rights 65 “Speciesism” 65 Rights 65 Objectivity 66 Practical Issue 66 Animal-to-Human Transplantation 67 3.10 Company Profiles - Major Players in Biological Implants Market 75 Aastrom Biosciences, Inc. (USA) 75 Admedus Ltd. (Australia) 77 ADODERM GmbH (Germany) 78 Alphatec Spine, Inc. (USA) 79 Anteis SA (Switzerland) 80 Arthro Kinetics Plc (UK) 82 Asterand Plc (UK) 83 AutoTissue GmbH (Germany) 84 Baxter Healthcare Corporation (USA) 85 Biopolymer GmbH & Co. KG (Germany) 86 BioTissue Technologies AG (Germany) 87 CR Bard, Inc. (USA) 88 CryoLife®, Inc. (USA) 89 DePuy Orthopaedics, Inc. (USA) 91 Edwards Lifesciences Corporation (USA) 92 Exactech, Inc. (USA) 95 Fidia Farmaceutici SpA (Italy) 96 Inion OY (Finland) 97 Integra LifeSciences Corporation (USA) 101 IOP, Inc. (USA) 103 LifeCell Corporation (USA) 105 Maxigen Biotech, Inc. (Taiwan) 106 Medtronic, Inc. (USA) 107 NuVasive, Inc (USA) 109 Organogenesis, Inc. (USA) 110 Prollenium Medical Technologies, Inc. (USA) 110 RTI Biologics, Inc. (USA) 112 Seikagaku Corporation (Japan) 120 Stryker Corporation (USA) 121 Wright Medical Technology, Inc. (USA) 122 3.11 Major Activities in Biological Implants Market 124 Vivex Biomedical Partners with Akron Biotech 124 Valeant Pharmaceuticals Sells Filler and Toxin Assets to Galderma 124 Bioheart Seeks Partnership in South Africa 124 Medtronic Buys Stake in Covidien worth US$ 42.9 billion 125 aap Divests the aap BM to botiss 125 Zimmer Holdings to Acquire Biomet 125 Bioheart Alliances with MCT 125 CryoLife Buys Distribution Rights for ProCol® Vascular Bioprosthesis 126 Sorin Group Acquires Cannulae Manufacturing Activities from Bioengineering Laboratories 126 Integra LifeSciences Acquires Covidien’s DuraSeal Products 126 Cortec Group Acquires IOP Ophthalmics 126 LifeCell Corporation Buys Advanced Adipose Tissue Injector 127 Organogenesis Acquires Dermagraft® from Shire 127 RTI and Yankee Alliance Enters into Agreement 127 Wright Medical Group Acquires Biotech International 127 Amedica Corp., Collaborates with Kyocera Industrial Ceramics Corporation 128 Bioheart Contracts with GSCG to Offer Bioheart Therapies 128 Boston Scientific Acquires Bard Electrophysiology 128 Bioheart Inks an Agreement with Anosis for the Product Distribution in the Middle East 129 Allosource Inks Strategic Manufacturing Partnership Agreement with Humacyte 129 Bioheart Alliances with AFRIMID for the Stem Cell Product Distribution in Uganda 129 Bioheart Inks a License Agreement with Invitrx for Adipose Derived Stem Cells 130 Bard Acquires Medafor, Inc. 130 RTI Biologics Acquires Pioneer® Surgical Technology 130 NuVasive® Acquires Ohio based ANC 130 AlloSource Partners with FOCOS 131 NuVasive® Inaugurates New Office in Japan 131 Wright Medical Group Acquires BioMimetic Therapeutics Inc. 131 ReNeuron Collaborates with Cell Therapy Catapult on New Cell Manufacturing Technologies 132 Alphatec Spine Acquires Phygen LLC 132 Bioheart Partners with Stemlogix 132 AlloSource Inaugurates New Headquarter Campus 133 Stemgent Procures Rights on Asterand’s Human Tissue Business 133 AlloSource Partners with LifeGift 134 Johnson & Johnson Acquires Synthes to Build up Orthopedics Business Worldwide 134 CryoLife Buys Hemosphere 134 Premier Healthcare Alliance Grants Supply Contract to Advanced Biologics for OsteoAMP® Product Line 134 Abbott Inks Partnership Agreement with St. Jude Medical 135 Sanofi Acquires Pluromed 135 Kuros and Synthes Enters into Licensing and Development Agreement 136 Synovis, Now a Subsidiary of Baxter 136 MTF Enters into Partnership with CONMED/Linvatec 137 Medicis Completely Acquires Graceway 137 UK Government Takes Initiative to Develop Elite Cell Therapy Centre 137 Integra LifeSciences Acquires Ascension Orthopedics 137 AlloSource Collaborates with ARM and MDMA 138 Medtronic Takes Over Salient Surgical Technologies and PEAK Surgical 138 Extension of Contract Manufacturing Arrangements by ReNeuron with Angel Biotechnology for ReNoo1 stroke therapy 139 Arterius Ltd. Signs a New Research Collaboration 139 BioMD Adopts New Corporate Identity 139 ACT Collaborates with Roslin Cells for Commercialization of ACT's Blastomere Technology 139 Misonix Enters into Exclusive Agreement with Anika Therapeutics 140 Stryker Buys Orthovita 140 CryoLife Acquires Cardiogenesis 141 Integra LifeSciences Completes Acquisition of SeaSpine 141 Sanofi-Aventis Completes Acquisition of Genzyme Corporation 142 RTI and Alphatec Spine Enters into a Processing and Supply Agreement 142 NuVasive and AlloSource Enters into Licensing Agreement 142 Medtronic Acquires Osteotech 142 ArunA Biomedical Joins Hands with Mediatech 143 Xenogenics Completes the Acquisition of the Assets of Ideal BioStent 143 ART Raises US$ 8.5M for Biodegradable Stents 143 Zimmer Dental and RTI Biologics Signs Agreement for Dental Biologic Implants 144 VertiFlex’s Minimally Invasive Spine Reconstruction Portfolio Acquired by Exactech 144 Alphatec Spine and Parcell Spine Signs Exclusive Distribution Agreement 144 Piramal Healthcare Acquires BioSyntech Assets 145 Exactech Acquires Brighton Partners and its Proprietary Knee Replacement Technology 145 Landec Corporation Completes Acquisition of Lifecore Biomedical 145 Alphatec Holdings Acquires Scient’x Groupe 145 Merz Acquires BioForm Medical 146 Anika Therapeutics Acquires Fidia Advanced Biopolymers 146 Osteotech and Community Tissue Services (CTS) Enter into a Ten Year Tissue Supply Agreement 146 Celling Technologies Enters into Exclusive Agreement with Tissue Genesis 147 Alphatec Spine and ETEX Corporation Sign a Supply and Distribution Agreement 147 Integra LifeSciences Acquires the Assets of Innovative Spinal Technologies 148 Synovis Life Technologies Acquires the Assets of Pegasus Biologics 148 Intercytex Group Acquires Stem Cell Company, Axordia Limited 148 Medical Ventures Corp., (MEV) Renamed to Neovasc Inc., (NVC) with Two Corporate Acquisitions and US$ 8.3 Million Financing 149 Biohorizons and Osteotech Signs Distribution Agreement for Supplying Osteotech's Products to the Global Dental Market 149 Osteotech Signs Agreement with Harvest Technologies for Distribution Rights of BMAC™ System 149 Alphatec Holdings Acquires Worldwide License for Innovative Expandable Inter-body/ Vertebral Body Replacement Technology 150 Organogenesis Acquires NanoMatrix Inc 150 Integra LifeSciences Acquires IsoTis and Attain Global Leadership in Orthobiologics 150 Organogenesis Inc. Signs MoU with National Tissue Engineering Center of China 151 Tutogen Medical, Inc. Signs New Tissue Supply Agreement and Extends Existing Agreement 151 Regeneration Technologies Merges with Tutogen Medical 151 Integra Creates a New Global Leader in Orthobiologics with New Acquisition (IsoTis) 151 Osteotech Signs Tissue Supply Agreement with LifeNet Health 152 RTI Signs Distribution and Supply Agreement with Stryker Corporation 152 Tutogen Medical Signs an International Distribution Agreement with Coloplast Corporation 153 Osteotech and Novation Sign Single Source Agreement 153 IsoTis Expands Existing Private Label Agreement with AlloSource for First Generation DBM Products 153 RTI Signs Ten Year Distribution Agreement with Zimmer Holdings for New Allograft Paste Implant 153 Tutogen Medical Signs Distribution Agreement with Zimmer Holdings 154 Alphatec Holdings Acquires Technology License for Minimally Invasive Spinal Surgery Market 154 Advanced Cell Technology Buys Technology Assets of Infigen 154 NuVasive Buys Biologic Product Platform 155 License Agreements between Alphatec and Scient’x for Manufacture and Distribution of Spine Implants 155 Musculoskeletal Transplant Foundation Announces Three Year Deal with Affinergy 156 Encore Medical Acquires Cefar AB of Sweden 156 CryoLife Enters into Alliance with Bioform Medical for Development and Marketing of BioGlue® 156 Stem Cell Innovations Enters into Collaboration with ND TWente University for Assessment of Bone Forming Capability of Pluricells 157 Affinergy Signs Development Agreement with Synthes 157 Affinergy Joins Hands with DuPont for New Bio-based Materials 157 Acquisition of Exclusive Option Rights of Cell Technology by Bioheart 157 Axordia Enters into Collaboration with Lombard Medical Technologies for Developing of Therapy for Coronary Artery Disease 158 Smith & Nephew Buys OsteoBiologics Inc. 158 Alphatec Spine and OsteoBiologics Enter into an Agreement for Distribution of Spine Products 158 Bioheart Signs Agreement to Use Cleveland Clinic’s Proprietary Methods 159 Cambrex Buys Cutanogen Corporation 159 Inion Enters into Alliance with Aesculap for Distribution of its Spinal Product Range across the United States and Canada 159 Inion Enters into an Agreement with the University of Cambridge for Advancement of its Bioactive Products 159 Inion and Richard Wolf Medical Instruments Enter into Agreement for Distribution of Sports Medicine Product Range 160 International Distribution Agreement Signed by OsteoBiologics and CONMED Linvatec for Cartilage and Bone Repair Product Range 160 Millenium Biologix Enters into License Agreement Exclusively to Improve ACTES(TM)-C 160 OsteoBiologics Enters into Collaboration with Nexa Orthopedics for Surgical Extremities 160 Genzyme Acquires Verigen AG 161 CryoLife and Endologix Enter into a Development Agreement for BioFoam 161 3.12 Major Product Innovations/Launches in Biological Implants Market 162 BioHorizons Launches Novel Range of Xenograft Products 162 First Implantation of CROWN PRT™ Heart Valve of Sorin Group 162 FDA Approves Solo Smart™, the New Tissue Valve Technology Product of Sorin Group 162 Caredx and Allegheny General Hospital Initiate D-OAR Study 163 Bioheart Introduces the First Combination Stem Cell Treatment 163 Bioheart Initiates two Clinical Trials in India 163 Aastrom Buys Cell Therapy and Regenerative Medicine Business unit of Sanofi 164 Elixir Medical Announces Receipt of CE Mark Approval for Bioresorbable DESolve® 100 Novolimus Eluting Coronary Scaffold System 164 Aperion’s Z-Lig ACL Replacement Device Gains CE Mark Approval 164 Cytori Receives Patent for Wound Healing Methods Utilizing Adipose-Derived Regenerative Cells 165 Nobel Biocare Unveils the New creos™ Allograft Regenerative Solutions 165 RTI Surgical’s FortivaTM Certified by CE Mark 166 Zimmer and Allosource Introduces Bone Graft Substitute Products 166 ACell Introduces novel MatriStem® Multilayer Wound Matrix Device Solution for Difficult-to-Heal Deep Wounds 166 Zimmer Introduces Ready-to-Use Bone Graft Substitutes 166 ACell Widens Portfolio of MatriStem® Pelvic Floor Matrix Products 167 DePuy Synthes Spine Introduces Conform Sheet™ 167 First implantation of Elixir Medical’s DESolve® Novolimus Eluting Coronary Scaffold System in Europe 167 Smith & Nephew Launches Advanced Bio-Composite Material for Arthroscopic Surgery Applications 168 LifeCell Corp., Launches REVOLVE™ System 168 BIOTRONIK Reports Use of First–in–Human Use of Bioabsorbable Magnesium DREAMS Scaffold 169 Allosource Introduces AlloMend™ 169 Orthofix in Association with MTF Launches Trinity® ELITE™ Allograft 170 Orthofix and MTF Launches Trinity ® ELITE™ Allograft 170 Elixir's DESolve® Novolimus Eluting Bioresorbable Coronary Scaffold System Certified by CE 170 ISTO Technologies Takes Control of DeNovo ET Cartilage Repair Technology Program 171 Medical Receives European Approval Portico™ Transcatheter Aortic Heart Valve and Transfemoral Delivery System 171 Arterial Remodeling Technologies (ART) Announces First Human Use of Its Bioresorbable Stent 172 Edwards to Begin TRANSFORM Trial, for Assessing the Proprietary INTUITY Valve System 172 Scottish Medicines Consortium Acknowledges the Use of Allergan’s OZURDEX® (dexamethasone 700mcg intravitreal implant) in NHS Scotland 173 Edwards Attains FDA’s IDE for the US Clinical Trial of GLX next-generation tissue treatment platform 173 Integra LifeSciences Reinforces Spinal Product Portfolio Including a Stand-Alone, Zero-Profile Device for ALIF Procedures 173 FDA Approval for Organogenesis’ GINTUIT™ 174 Bioheart Buys Rights to Ageless 174 Integra Life Sciences Launches Integra® Allograft Wedge System for Extremity Reconstruction 175 Amedica Launches Valeo® VBR, Silicon Nitride Implant 175 Signature™, BIOMET’s New Personalized Patient Care System for Partial Knee Replacements 175 Advanced Cell Technology Successfully Completes Clinical Trial of Human Embryonic Stem Cell Transplant in Stargardt Patients 176 S3V Vascular Technologies Introduces first Bioabsorbable Endovascular Drug Coated Stent "3V-Avatar"in India 176 Sanofi In-Licenses Scil Technology’s Regenerative Treatment Program 177 Jude Medical Successfully carries out First Implant in European Clinical Trial Studying Portico Transcatheter Aortic Heart Valve 177 Exactech Begins Clinical Trial for the Innovative Cartilage Regeneration Technology 178 Airspeed Equity in Association with Bioheart Launches MyoStim and Biopace Products 178 ISTO Technologies’ InQu® Bone Graft Substitute and Extender Receive CE Mark 179 Medtronic Commences a Pivotal Trial for Engager™ Transcatheter Aortic Valve Implantation System 179 StemCells Inc. Carries World’s First Neural Stem Cell Transplant in a Spinal Cord Injury Patient 180 UK Medical Launches the First Ever Biodegradable Esophageal Stent 180 Curasan AG Receives European Approval for Cerasorb ® Foam 180 RTI Biologics Introduces New Meniscus Allograft Instrumentation 180 RTI Biologics Releases the BioAdapt™ DBM Foam 180 St. Jude Medica Announces First Successful Implant of Portico Transcatheter Heart valve 181 Wright Medical Introduces INBONE® II Total Ankle Replacement System 181 Urinary Incontinence Research Employing Celution® System Receives Approval in Japan 182 Tornier Introduces BioFiber® Surgical Mesh for Tendon Repair 182 Orthovita Unveils the Aliquot™ Directional Bone Tamp Device 183 CryoLife Introduces BioGlue®, a Novel Surgical Adhesive across Japan 183 US Patent to Cytori for Methods of Making Enhanced, Autologous Fat Grafts 183 Orthovita Introduces Vitoss BA2X, a Non-Structural Bone Void Filler 184 Cytori Receives Patent for Cell-Enriched Fat Grafting 184 Integra LifeSciences Launches Allograft Cancellous Sponge 185 Integra LifeSciences Launches Advanced Orthobiologics for Extremity Reconstruction 185 Abbott Announces the CE Marking on ABSORB in Europe, World's First Drug Eluting Bioresorbable Vascular Scaffold 186 Aperion Biologics Receives Project Grant for Therapeutic Discovery 186 NJ and MTF Edison Launches the Largest Acellular Dermal Allografts for Abdominal Wall Repair 186 Wright Medical Group Launches the XPANSION® Micrografting System 187 RTI Biologics Introduces Two Biologic Implants 187 Medicis’ Restylane® and Perlane® with Lidocaine Receives Approval 188 First Time Terminally Sterilized Allograft Dermis Successful in Reducing Condition Symptoms 188 Organogenesis Submits PMA for CelTx™ for FDA Approval 189 CONMED Linvatec Launches Matryx® Biocomposite Interference Screws of Various Sizes for PCL and ACL Reconstructions 189 CONMED Linvatec Unveils Bullseye™ Anatomic Cruciate Reconstruction System 190 LifeNet Health Introduces Vertigraft Cervical Bio-Implant with Preservon Technology 190 Integra LifeSciences Extends Accell Evo3 Product Line 191 Inion Reinforces Product Range in Spine and Specialty Orthopedics 191 Exactech Develops New Biological Implants for Knee Replacement Surgeries 191 RTI Biologics and Entrigue Surgical Develop Biological Implants for ENT Patients 192 IOP Introduces Advanced Amniotic Membrane Technology, Ambio5™ 192 RTI Unveils CopiOs®, the Proprietary Bovine Pericardium Membrane Implant in the Dental market 192 CryoLife to Distribute Hemostase MPH® through Sorin Group Canada 193 Osteotech's Plexur M™ Biocomposite Approved by FDA for Spinal Applications 193 Exactech Introduces Advanced Novation® Crown Cup Acetabular System 193 CE Mark for CryoLife’s BioGlue® Surgical Adhesive 194 IGAKI-TAMAI’s Bioabsorbable Stent Gains CE Mark Status for Peripheral Artery 194 RTI Introduces New BioCleanse® Meniscus 194 Mentor Launches New NeoForm™ Dermis for Breast Reconstruction 194 LifeCell Corporation Receives 510(k) Clearance for New Soft Tissue Repair Product 195 Inion Granted with US Patent for Bioactive Materials Technology 195 Japanese Ministry Endorses Alphatec’s NOVEL Titanium Product Family 195 FDA Approval to Exactech for Distribution of Equinox® Reverse Shoulder 196 U.S. FDA Grants 510(k) Clearance to Osteotech for Plexur™ P 196 Inion Product Range of BMI Widens with the Approval of ANCHRON™ in Europe 196 University of Rochester and StemCapture Unveil an Anticancer Stem Cell Implant Device 197 Pegasus Biologics’ Wound Dressing Receives FDA approval 197 Exactech Gains FDA Clearance for DBM with Bone Chips, OptecureTM +CCC 197 Bone Growth Stimulator – New Product of Alphatec Holdings 197 Exactech Adds Cemented Stem to its Hip System 198 Avecia Given £1m Grant to Develop Bioprocessing Technology for Generating Synthetic Skin for Burn Victims 198 Patent Licensing Agreement Signed between Bioheart Inc and Tricardia 198 Inion’s Novel Bioactive Technology Granted with US Patent 199 Pegasus Launches OrthADAPT™ Bioimplant - a Revolutionary New Biologic Scaffold for Orthopedic Soft Tissue Reinforcement 199 Inion Launches Biodegradable Spinal Implant in the EU 199 Affinergy Awarded SBIR Grant for Research on Medical Device Materials 199 3.12 Analysis by Tissue/Muscle 200 Exhibit 27. Biological Implants - Global Market Estimations & Predictions (2005 - 2020) by Tissue/Muscle for Orthopedic, Soft Tissue, Cardiovascular and Other in US$ Million 200 Exhibit 28. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Tissue/Muscle for Orthopedic, Soft Tissue, Cardiovascular and Other 201 3.12.1 Orthopedic 202 3.12.1.1 Global Orthopedic Biological Implants Market 202 Exhibit 29. Orthopedic Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 203 Exhibit 30. Orthopedic Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 204 3.12.1.2 North American Orthopedic Biological Implants Market 205 Exhibit 31. Orthopedic Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 205 Exhibit 32. Orthopedic Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 206 3.12.1.3 European Orthopedic Biological Implants Market 207 Exhibit 33. Orthopedic Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 207 Exhibit 34. Orthopedic Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 208 3.12.1.4 Asia-Pacific Orthopedic Biological Implants Market 209 Exhibit 35. Orthopedic Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 209 Exhibit 36. Orthopedic Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific (Graphical Representation Included) 210 3.12.1.5 Rest of World Orthopedic Biological Implants Market 211 Exhibit 37. Orthopedic Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 211 Exhibit 38. Orthopedic Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 212 3.12.2 Soft Tissue 213 3.12.2.1 Global Soft Tissue Biological Implants Market 214 Exhibit 39. Soft Tissue Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 214 Exhibit 40. Soft Tissue Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 215 3.12.2.2 North American Soft Tissue Biological Implants Market 216 Exhibit 41. Soft Tissue Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 216 Exhibit 42. Soft Tissue Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 217 3.12.2.3 European Soft Tissue Biological Implants Market 218 Exhibit 43. Soft Tissue Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 218 Exhibit 44. Soft Tissue Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 219 3.12.2.4 Asia-Pacific Soft Tissue Biological Implants Market 220 Exhibit 45. Soft Tissue Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 220 Exhibit 46. Soft Tissue Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific 221 3.12.2.5 Rest of World Soft Tissue Biological Implants Market 222 Exhibit 47. Soft Tissue Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 222 Exhibit 48. Soft Tissue Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 223 3.12.3 Cardiovascular 224 3.12.3.1 Global Cardiovascular Biological Implants Market 224 Exhibit 49. Cardiovascular Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 224 Exhibit 50. Cardiovascular Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 225 3.12.3.2 North American Cardiovascular Biological Implants Market 226 Exhibit 51. Cardiovascular Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 226 Exhibit 52. Cardiovascular Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 227 3.12.3.3 European Cardiovascular Biological Implants Market 228 Exhibit 53. Cardiovascular Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 228 Exhibit 54. Cardiovascular Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 229 3.12.3.4 Asia-Pacific Cardiovascular Biological Implants Market 230 Exhibit 55. Cardiovascular Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 230 Exhibit 56. Cardiovascular Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific 231 3.12.3.5 Rest of World Cardiovascular Biological Implants Market 232 Exhibit 57. Cardiovascular Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 232 Exhibit 58. Cardiovascular Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 233 3.12.4 Other (Dental, Ophthalmic and Urologic) 234 3.12.4.1 Global Other Tissue/Muscle Biological Implants Market 234 Exhibit 59. Other Tissue/Muscle Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 234 Exhibit 60. Other Tissue/Muscle Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 235 3.12.4.2 North American Other Tissue/Muscle Biological Implants Market 236 Exhibit 61. Other Tissue/Muscle Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 236 Exhibit 62. Other Tissue/Muscle Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 237 3.12.4.3 European Other Tissue/Muscle Biological Implants Market 238 Exhibit 63. Other Tissue/Muscle Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 238 Exhibit 64. Other Tissue/Muscle Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 239 3.12.4.4 Asia-Pacific Other Tissue/Muscle Biological Implants Market 240 Exhibit 65. Other Tissue/Muscle Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 240 Exhibit 66. Other Tissue/Muscle Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific 241 3.12.4.4.5 Rest of World Other Tissue/Muscle Biological Implants Market 242 Exhibit 67. Other Tissue/Muscle Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 242 Exhibit 68. Other Tissue/Muscle Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 243 3.13 Analysis by Origin 244 Exhibit 69. Biological Implants - Global Market Estimations & Predictions (2005 - 2020) by Origin for Allograft and Xenograft in US$ Million 244 Exhibit 70. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Origin for Allograft and Xenograft 245 3.13.1 Allograft 246 3.13.1.1 Global Allograft Implants Market 246 Exhibit 71. Allograft Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 246 Exhibit 72. Allograft Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 247 3.13.1.2 North American Allograft Implants Market 248 Exhibit 73. Allograft Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 249 Exhibit 74. Allograft Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 250 3.13.1.3 European Allograft Implants Market 251 Exhibit 75. Allograft Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 251 Exhibit 76. Allograft Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 252 3.13.1.4 Asia-Pacific Allograft Implants Market 253 Exhibit 77. Allograft Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 253 Exhibit 78. Allograft Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific 254 3.13.1.5 Rest of World Allograft Implants Market 255 Exhibit 79. Allograft Implants – Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 255 Exhibit 80. Xenograft Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 256 Exhibit 81. List of Allograft Banks 256 3.13.2 Xenograft 257 3.13.2.1 Global Xenograft Implants Market 257 Exhibit 82. Xenograft Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 257 Exhibit 83. Xenograft Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 258 3.13.2.2 North American Xenograft Implants Market 259 Exhibit 84. Xenograft Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 259 Exhibit 85. Xenograft Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 260 3.13.2.3 European Xenograft Implants Market 261 Exhibit 86. Xenograft Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 261 Exhibit 87. Xenograft Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 262 3.13.2.4 Asia-Pacific Xenograft Implants Market 263 Exhibit 88. Xenograft Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 263 Exhibit 89. Xenograft Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific 264 3.13.2.5 Rest of World Xenograft Implants Market 265 Exhibit 90. Xenograft Implants – Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 265 Exhibit 91. Xenograft Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 266 3.14 Analysis by Mode of Administration 267 Exhibit 92. Biological Implants - Global Market Estimations & Predictions (2005 - 2020) by Mode of Administration for Surgical and Injectable in US$ Million 267 Exhibit 93. Biological Implants – Global Market Shares (2010, 2015 & 2020) by Mode of Administration for Surgical and Injectable 268 3.14.1 Surgical 269 3.14.1.1 Global Surgical Biological Implants Market 269 Exhibit 94. Surgical Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 269 Exhibit 95. Surgical Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 270 3.14.1.2 North American Surgical Biological Implants Market 271 Exhibit 96. Surgical Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 271 Exhibit 97. Surgical Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 272 3.14.1.3 European Surgical Biological Implants Market 273 Exhibit 98. Surgical Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 273 Exhibit 99. Surgical Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 274 3.14.1.4 Asia-Pacific Surgical Biological Implants Market 275 Exhibit 100. Surgical Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 275 Exhibit 101. Surgical Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific 276 3.14.1.5 Rest of World Surgical Biological Implants Market 277 Exhibit 102. Surgical Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 277 Exhibit 103. Surgical Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 278 3.14.2 Injectable 279 3.14.2.1 Global Injectable Biological Implants Market 279 Exhibit 104. Injectable Biological Implants – Global Market Estimations & Predictions (2005 - 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million 279 Exhibit 105. Injectable Biological Implants – Global Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World 280 3.14.2.2 North American Injectable Biological Implants Market 281 Exhibit 106. Injectable Biological Implants – North American Market Estimations & Predictions (2005 - 2020) by Country for the United States and Canada in US$ Million 281 Exhibit 107. Injectable Biological Implants – North American Market Shares (2010, 2015 & 2020) by Country for the United States and Canada 282 3.14.2.3 European Injectable Biological Implants Market 283 Exhibit 108. Injectable Biological Implants – European Market Estimations & Predictions (2005 - 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe in US$ Million 283 Exhibit 109. Injectable Biological Implants – European Market Shares (2010, 2015 & 2020) by Country for Germany, United Kingdom, France, Switzerland, Russia and Rest of Europe 284 3.14.2.4 Asia-Pacific Injectable Biological Implants Market 285 Exhibit 110. Injectable Biological Implants – Asia-Pacific Market Estimations & Predictions (2005 - 2020) by Country for Australia, Japan, China, India, South Korea and Asia-Pacific in US$ Million 285 Exhibit 111. Injectable Biological Implants – Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Australia, Japan, China, India, South Korea and Rest of Asia-Pacific 286 3.14.2.5 Rest of World Injectable Biological Implants Market 287 Exhibit 112. Injectable Biological Implants –Rest of World Market Estimations & Predictions (2005 - 2020) by Country for Israel, Brazil, South Africa and Other Countries in US$ Million 287 Exhibit 113. Injectable Biological Implants – Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, Brazil, South Africa and Other Countries 288 3.15 Biological Implants – Market Outlook 289 4. PRODUCT/TECHNOLOGY RESEARCH 290 4.1 Introduction 290 Medical Implants 290 Concerns Associated with Medical Implants 290 Microbial Contamination of the Implant 290 Inflammation due to implantation 291 Implant induced coagulation 291 Bioimplants 291 4.2 Segmentation of Biological Implants 292 Segmentation by Tissue/Muscle 292 Soft Tissue Biological Implants 292 Soft tissue implants are used for the following purposes: 292 Biological Implants in Cosmetic Surgery 292 Lip Augmentation Using Bioimplants: 292 Allograft Implants Used in Lip Augmentation: 292 Types and Characteristics of Various Allograft Implants 292 Alloderm 292 Apligraft 293 Cosmoderm I & 2 293 Cosmoplast 293 Cymetra or Micronized Alloderm 293 Cymetra should not be used in the following cases 294 Precautions 294 Fascian 294 Surgisis Soft Tissue Graft & Surgisis ES Soft Tissue Graft 294 Self Derived (Autologous) Implants & Injectables 295 Types and Characteristics of Autologous Implants 295 Autologen 295 Dermis Grafts 295 Dermis Fat Grafts 295 Fascia Grafts 295 Fat Grafting, Transfer or Transplanting 295 Drawbacks 295 Isolagen 296 Scar Tissue Grafting 296 Tendon Grafting 296 Application Biological Implants 296 Function and Use of Biological Implants 296 Application of Biological Implants in ENT surgery 297 Location of the Bioimplant: Middle Ear 297 Ossicle Replacement Draws Mixed Response 297 Tympanoplasty 297 Traumatic Perforation Using Fibrin-coated Collagen 297 Location of the Bioimplant: Paranasal Sinuses and Cranial Bones 298 Orbital Wall Reconstructions Using Allogenic Materials 298 Location of the Bioimplant: Bone and Cartilage of the Nose 298 Allogenic Materials to Develop Cartilage 298 Septal Abscess 298 Soft Tissue Implants 298 Location of the Bioimplant: Base of the Skull 299 Allogenic Materials to Treat Dural Defects 299 Allogenic Materials Required to Accomplish Duraplasty 299 Application of Fibrin Glues in ENT Surgeries 299 Location of the Bioimplant: Trachea/Larynx 300 Replacement of Trachea Using Solvent-preserved Allogenic Variety of Trachea 300 Various Disorders of Vocal Cord 300 Location of the Bioimplant: Skin 300 Process of Skin Replacement 300 Wrinkle Lift Treatment 300 Global Market Analysis for Cosmetic Surgery 301 Exhibit 114. Cosmetic Surgery – Global Market Estimations & Predictions (2005 - 2020) for Cosmetic Surgery in North America, Europe, Asia, and Rest of World in US$ Billion 301 Exhibit 115. Cosmetic Surgery – Global Market Shares (2010, 2015 & 2020) for Cosmetic Surgery in North America, Europe, Asia – Pacific and Rest of World 302 Orthopedic Biological Implants 302 Bone Graft Substitutes 302 Osteoinductive Agents - Substitute for Bone Allografts 303 Fibrin Matrix 303 Cardiovascular Biological Implants 304 Other (Dental, Ophthalmic, Urologic) 304 Other Tissue/Muscle Biological Implant Products 304 Dental Biological Implants 305 Ophthalmic Biological Implants 305 4.3 Segmentation by Origin of Biological Implants 305 Allograft and Xenograft Implants 305 Autografts and their Limitations 305 Utilization of the Allograft Bone Tissue 306 Limitations of the Process 306 Few Disadvantages of Using Allografts 307 Preventive Measures for Warding Infection 307 Bone Grafting 307 Advancements 307 Xenografts 308 Using Valved Porcine Xenografts in the Right Ventricle Outlet for Congenital Anomalies 308 Other Avenues of Research 309 L-Hydro Method 309 Allograft Biological Implants 309 Allograft Bone Tissue – Processing 309 Preparation for Biotransplantation 309 Allograft Bone Tissue 310 Base Tissue Segment 310 Processing of Allograft Bone Tissue 311 Processing of Grafton ® DBM – A Biological Implant Product of Osteotech 311 CXC TECHNOLOGY 312 Process of Tissue Processing Using Tutogen’s Tutoplast® 312 Process of Manufacture and Processing of Allografts 313 Quality Assurance Test 313 Stentless Porcine Xenograft (Mitral Valve Replacement) 313 Mitral Valve Replacement 313 4.4 Segmentation by Mode of Administration 314 Injectable Fillers for Soft Tissue Augmentation 314 Types of Augmentation Materials 314 Osteogenic Injectable Bone Substitutes 315 Hyaluronic Acid 315 Biological Synthesis 315 Biological Functions 316 HA and Cancer Metastasis 317 Appilcations 317 In Medicine 317 In Cosmetics 317 For Horses 318 Industrial Production of HA 318 Surgical Biological Implants 318 Organ Transplantation 318 3D-Bioprinting 319 4.5 Biological Implants – Research Briefs 320 Magnesium Surgical Implants to be Biodegradable and Influence the Bone Development 320 Autografts May be Useful for ACL Reconstructions 320 Developing Novel Nerve Repair Technology 321 Southampton Team of Scientists and Doctors Use 3D Printed Implant and Bone Stem Cell Graft for Successful Hip and Stem Cell Surgery 322 Young Athletes with Knee Pain Might Try Meniscus Transplant 322 Cell Recruitment by Amnion Chorion Grafts Promotes Neovascularization 323 Technological Developments Increase Long Term Survival of Transplanted Hearts in all Species 323 Rejection in Xenotransplantation 324 Interspecies Transplantation is Successful in the Initial Step in a Novel Process for Diabetes Treatment 325 Coatings Can Improve Functioning of Medical Implants 326 Engineered Biomaterial Could Improve Success of Medical Implants 327 Grafts from Bone Marrow Can Provide Relief to Patients Having Lower Back Pain 328 Nasal Lining to Breach Blood/Brain Barrier 329 Stem Cells Used to Fill Gaps in Bones 329 Processing autologous stem cells in the operating theatre 330 Investigators Expedite Success Rate of Tooth Implants 330 Investigators Apply Coating of Bioactive Film on Spinal Polymer Implants to Improve Bonding with Bone 331 Now Wooden Implants Substituting Damaged Bones 332 Post Stem Cell Transplantations, Survivors at Higher Risk of Developing Heart Disease 332 Gene Therapy to Cure Bone Defects 334 Liquorice Provides Clue to Cleaner Medical Implants 335 New Compound that could be used as a Substitute for Bone Glue Developed by Researchers 336 Human Tissue - Textile Developed by Cytograft Researchers 336 Xenotransplantation - Therapy for Type 1 Diabetes 337 Impact of Classical Music on Organ Transplant Rejection Revealed In Mice 338 Building Bone from Cartilage: Orthopedic Researchers Take the Road Less Travelled 338 Oocyte-Producing Stem Cells Identified from Human Ovaries 339 New Method of Cartilage Graft Developed for Bone Regeneration 339 IDIBELL Researchers Develops a Protocol for Transplanting Pig Cells to Regenerate Human Cartilage 340 Scientists Develop 'Living Bandage' for Speedy Healing Process 341 New Nanocomposite Materials to be used in Microturbines, Microreactors, and Bioimplants 341 Expanding the Pool of Liver Grafts and Transplants 342 A Better Disc for Back Repair 342 Russia Approves First Xenotransplantation based Therapeutics for Treating Diabetes 343 New Bioprosthetic Tissue Heart Valve for Severe Aortic Stenosis Shown to Save Lives 343 New Bone-Hard Biomaterial for Surgical Screws 344 A Brighter Future for Retinal Implants 344 Placenta – derived Stem Cells May Help Sufferers of Lung Diseases 345 First Ever System of Human Nerve Cell Tissue Engineered 345 Freeze –Dried Tendon Implants Loaded with Gene Therapy Prove Effective in Mice 346 Brain Implants to Restore Vision 347 Restoring Damaged Knees 347 Patients Who Receive Kidneys from Older Donors Do Well 348 V. CORPORATE DIRECTORY 349 VI. PATENTS INFORMATION 365
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